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- Table of Contents
Facts about Protein salvador homolog 1.
Phosphorylation of YAP1 by LATS1/2 inhibits its translocation to the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is needed for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues.
Human | |
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Gene Name: | SAV1 |
Uniprot: | Q9H4B6 |
Entrez: | 60485 |
Belongs to: |
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No superfamily |
45 kDa WW domain protein; hWW45; protein salvador homolog 1; salvador homolog 1 (Drosophila); SAV; WW domain-containing; WW45salvador; WWP4,1700040G09Rik
Mass (kDA):
44.634 kDA
Human | |
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Location: | 14q22.1 |
Sequence: | 14; NC_000014.9 (50633104..50668306, complement) |
Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines.
Nucleus. Cytoplasm.
PMID: 11027580 by Valverde P.; Cloning, expression and mapping of hWW45, a novel WW-domain containing gene.
PMID: 15688006 by Chan E.H.Y., et al. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.