SAP18 Antibodies

AND SAP18 ELISA kits, SAP18 Proteins

Many biological assays use antibodies to detect SAP18, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SAP18 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SAP18 antibodies...

We validate the specificity of these antibodies to SAP18 by testing them on tissues known to express SAP18 positively and negatively. Browse below to find the SAP18 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SAP18 Infographic by Boster Bio

All SAP18 Products

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Product

Figures

Specificity

Applications

Price

SAP18 (NM_005870) Human Recombinant Protein

$813
Cat # PROTO00422
20 µg

SAP18 (NM_005870) Human Over-expression Lysate

Human

$628
Cat # LS010284
100 µg

Anti-SAP18 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A06381-1
100 μg/vial

SAP18 Overview

Facts about Histone deacetylase complex subunit SAP18.

SAP18 3D structure. Source: alphafold

Histone deacetylase complex subunit SAP18 (SAP18)

Component of the SIN3-repressing complex.
Enhances the capacity of SIN3-HDAC1-mediated transcriptional repression.

When tethered to the promoter, it may direct the creation of a repressive complex to core histone proteins. Auxiliary part of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs.

Gene Information

Human
Gene Name:	SAP18
Uniprot:	O00422
Entrez:	10284

Family

Belongs to:

SAP18 family

Alternative Names

2HOR0202cell growth inhibiting protein 38; Cell growth-inhibiting gene 38 protein; cell growth-inhibiting protein 38; histone deacetlyase complex subunit SAP18; histone deacetylase complex subunit SAP18,18 kDa Sin3-associated polypeptide; MGC27131; SAP18P; Sin3A-associated protein, 18kDa; Sin3-associated polypeptide p18; sin3-associated polypeptide, 18 kDa; sin3-associated polypeptide, p18

Molecular Weight

Mass (kDA):
17.561 kDA

Genomic Context


Human

Location:	13q12.11
Sequence:	13; NC_000013.11 (21140514..21149097)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus. Cytoplasm. Nucleus speckle. Shuttles between the nucleus and the cytoplasm (PubMed:16314458). Colocalizes with ACIN1 and SRSF2 in nuclear speckles (PubMed:20966198).

Diseases

Atypical Small Acinar Proliferation Of The Prostate Gland
Carcinoma
Neoplasms
Retinoblastoma
Basal Cell Carcinoma
Pallister-hall Syndrome
Maple Syrup Urine Disease
Teratocarcinoma
Malignant Tumor Of Cervix
Coinfection
Tumor Angiogenesis
Medulloblastoma
Mycoses

Ectopic Tissue
Neurofibrillary Tangles
Rubinstein-taybi Syndrome
Infective Disorder
Salivary Gland Diseases
Kyphosis Deformity Of Spine
Basal Cell Nevus Syndrome

Interacting Proteins

HDAC1
INCA1
PNN
RBM39

Pathways

Mrna Processing
Rna Interference
Embryo Development
Mrna Splicing
Reverse Transcription
Cell Cycle
Histone Deacetylation
Cell Death
Cell Growth
Transport
Cell Adhesion
Gene Silencing
Programmed Cell Death

Nuclear Export
Macroautophagy
Translation
Cell Differentiation
Gonad Development
Chromatin Remodeling
Cell Proliferation

PTMs

Deacetylation
Phosphorylation

Cleavage
Acetylation

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SAP18

References

PMID: 9150135 by Zhang Y., et al. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.

PMID: 12665594 by Schwerk C., et al. ASAP, a novel protein complex involved in RNA processing and apoptosis.