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, No Gclids
S1PR1 Antibodies
AND S1PR1 ELISA kits, S1PR1 Proteins
Many biological assays use antibodies to detect S1PR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with S1PR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop S1PR1 antibodies...
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S1PR1 Infographic by Boster Bio
All S1PR1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1509
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1509
1 kit, containing one 96-well plate and all necessary reagents
S1PR1 Overview
Facts about Sphingosine 1-phosphate receptor 1.
Sphingosine 1-phosphate receptor 1 (S1PR1)
G-protein coupled receptor for its bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that appears to be coupled to the G(I) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases.
Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate.
Gene Information
| Human | |
|---|---|
| Gene Name: | S1PR1 |
| Uniprot: | P21453 |
| Entrez: | 1901 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
CD363 antigen; CD363; CHEDG1; D1S3362; EDG1; EDG-1; EDG1edg-1; Endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; FLJ58121; S1P receptor 1; S1P receptor Edg-1; S1P1; S1P1ECGF1; S1PR1; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor EDG1; Sphingosine 1-phosphate receptor Edg-1; sphingosine-1-phosphate receptor 1
Molecular Weight
Mass (kDA):
42.811 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p21.2 |
| Sequence: | 1; NC_000001.11 (101236749..101241520) |
Tissue Specificity
Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.
Diseases
- Malignant Neoplasms
- Inflammation
- Tumor Angiogenesis
- Neoplasms
- Sclerosis
- Multiple Sclerosis
- Pertussis
- Asthma
- Cell Invasion
- Tissue Adhesions
- Neoplasm Metastasis
- Edema
Interacting Proteins
- CD69
Pathways
- Angiogenesis
- Cell Migration
- Localization
- Pathogenesis
- Transport
- Bone Remodeling
- Cell Motility
- Sprouting Angiogenesis
- Cell Proliferation
- Tube Formation
- Reverse Transcription
- Cell Growth
- Bone Resorption
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/S1PR1
bosterbio.com/bosterbio-gene-info-cards/S1PR1
References
PMID: 2160972 by Hla T., et al. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein- coupled receptors.
PMID: 9409733 by An S., et al. Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.