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LPAR1 Antibodies
AND LPAR1 ELISA kits, LPAR1 Proteins
Many biological assays use antibodies to detect LPAR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LPAR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LPAR1 antibodies...
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LPAR1 Infographic by Boster Bio
All LPAR1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, WB
$560
Cat # M02782-1
100 µl
Cat # M02782-1
100 µl
LPAR1 Overview
Facts about Lysophosphatidic acid receptor 1.
Lysophosphatidic acid receptor 1 (LPAR1)
Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades through the G(I)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins.
Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling activates an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040).
Gene Information
| Human | |
|---|---|
| Gene Name: | LPAR1 |
| Uniprot: | Q92633 |
| Entrez: | 1902 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
EDG2; edg-2; EDG2Lysophosphatidic acid receptor Edg-2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor2,; GPCR26; GPR26; LPA receptor 1; LPA1; LPA-1; LPA1vzg-1; LPAR1; lysophosphatidic acid receptor 1; Mrec1.3; rec.1.3; ventricular zone gene 1; VZG1; vzg-1
Molecular Weight
Mass (kDA):
41.109 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q31.3 |
| Sequence: | 9; NC_000009.12 (110873252..111038998, complement) |
Tissue Specificity
Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes (PubMed:9070858). Detected in lung fibroblasts from bronchoalveolar fluid from patients with idiopathic pulmonary fibrosis (PubMed:18066075). Detected in bone marrow-derived mesenchymal stem cells (PubMed:19733258).
Subcellular Localizations
Cell surface. Cell membrane; Multi-pass membrane protein. Endosome. Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Invasion
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Adenocarcinoma
- Prostatic Neoplasms
- Inflammation
- Liver Neoplasms
- Malignant Neoplasm Of Pancreas
- Malignant Neoplasm Of Prostate
- Neuroblastoma
- Lung Neoplasms
Pathways
- Cell Migration
- Pathogenesis
- Cell Motility
- Cell Proliferation
- Reverse Transcription
- Secretion
- Vasodilation
- Dna Methylation
- Fibroblast Proliferation
- Localization
- Platelet Aggregation
- Prostaglandin Secretion
- Embryo Development
PTMs
- Phosphorylation
Research Areas
- Apoptosis
- GPCR
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LPAR1
bosterbio.com/bosterbio-gene-info-cards/LPAR1
References
PMID: 9070858 by An S., et al. Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid.
PMID: 9069262 by Moolenaar W.H., et al. Lysophosphatidic acid: G-protein signalling and cellular responses.