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- Table of Contents
Facts about Protein S100-A14.
Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that's under transcriptional control of P53/TP53. Does not bind calcium.
Human | |
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Gene Name: | S100A14 |
Uniprot: | Q9HCY8 |
Entrez: | 57402 |
Belongs to: |
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S-100 family |
protein S100-A14; S100 calcium binding protein A14; S100 calcium-binding protein A14; S100A15BCMP84breast cancer membrane protein 84; S114
Mass (kDA):
11.662 kDA
Human | |
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Location: | 1q21.3 |
Sequence: | 1; NC_000001.11 (153614255..153616917, complement) |
Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes.
Cytoplasm.
PMID: 11944983 by Pietas A., et al. Molecular cloning and characterization of the human S100A14 gene encoding a novel member of the S100 family.
PMID: 21559403 by Jin Q., et al. S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE).