Reticulon-4 receptor Antibodies

Reticulon-4 receptor (RTN4R)

Functions as receptor to the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Can also bind heparin (By similarity).

Intracellular signaling cascades are triggered through the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200).

Gene Information

Human
Gene Name:	RTN4R
Uniprot:	Q9BZR6
Entrez:	65078

Family

Belongs to:
Nogo receptor family

Alternative Names

NgR; NgR1; Nogo R; Nogo receptor; Nogo-66 receptor; NogoR; NOGORUNQ330/PRO526; reticulon 4 receptor; reticulon-4 receptor; RTN4R

Molecular Weight

Mass (kDA):
50.708 kDA

Genomic Context

Human
Location:	22q11.21
Sequence:	22; NC_000022.11 (20241415..20268318, complement)

Tissue Specificity

Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney; not expressed in oligodendrocytes (white matter).

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Cell projection, axon. Perikaryon. Detected along dendrites and axons, close to synapses, but clearly excluded from synapses.

Diseases

• Nervousness
• Spinal Cord Injuries
• Injury Of Central Nervous System
• Sclerosis
• Brain Injuries
• Cerebrovascular Accident
• Multiple Sclerosis
• Schizophrenia
• Tissue Adhesions
• Alzheimer's Disease
• Trauma, Nervous System
• Arterial Occlusion

• Occlusion, Middle Cerebral Artery
• Cerebral Artery Occlusion
• Neuroblastoma
• Nerve Degeneration
• Experimental Autoimmune Encephalomyelitis
• Cns Disorder
• Traumatic Brain Injury

Interacting Proteins

• KIAA0319L

Pathways

• Regeneration
• Axon Regeneration
• Localization
• Locomotion
• Rna Interference
• Proteolysis
• Cell Adhesion
• Cell Migration
• Gene Silencing
• Brain Development
• Immune Response
• Neuroprotection
• Coagulation

• Cell Death
• Pathogenesis
• Cell Activation
• Dna Hypomethylation
• Aging
• Neurogenesis
• Protein Secretion

PTMs

• Phosphorylation

• Cleavage

• Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RTN4R

Boster Bio - Best Uses Of The RTN4R Marker

Are you curious about Steven Boster’s life? Learn more about Steven Boster's family and his history. You might also want to know more about his career. In this Boster bio, you'll find some useful information about His work and family. Continue reading to learn more about this pioneering inventor. You'll be pleased you did. You can contact me with any questions. I'm happy answer any questions you might be having!

History of Steven Boster

This page will provide information about Steven Boster’s past. You can obtain Steve Boster’s public information, including his current address, previous addresses, mobile and email details, and even his past addresses. You can also view his known relatives. You can filter your results by age and state to find out exactly who he was related to. To get started, sign up for an account. This will allow for you to search public data for any person, even Steve Boster.

Steve Boster was a Joliet, IL native, who was born on May 29, 1920. He died from COVID-19 on June 6, 2022. He was an army veteran and managed retail sales for many years. He was also a member of Concordia Hall in Staunton, VA. In addition to his son Jonathan, Steven is survived by his sister Tammy, four brothers, and numerous nieces and nephews. Steven Boster's extended family is large, and he is fondly remembered by many of his friends.

His work

His work with the RTN4R marker led him to identify a rare variation of RTN4, a genetic that regulates the structure, function, and organization of neural networks. This gene is located along chromosome 23q11.2, a known area of schizophrenia. Researchers focused their search for rare variants, mutations that have a significant impact upon the protein. Researchers discovered R292H, a single mutation that changed an amino acid from Argonine to Histidine in schizophrenia patients.

Further research on RTN4R suggests that it plays a significant role in synaptic stability and elimination. It is also believed that synaptic plasticity is controlled by the Rtn4r–RhoA signaling pathway. This scientist's work has opened up new research avenues on this gene. He focuses his attention on the role of the Rtn4R gene in synaptic removal.