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- Table of Contents
Facts about Reticulon-4 receptor.
Intracellular signaling cascades are triggered through the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200).
Human | |
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Gene Name: | RTN4R |
Uniprot: | Q9BZR6 |
Entrez: | 65078 |
Belongs to: |
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Nogo receptor family |
NgR; NgR1; Nogo R; Nogo receptor; Nogo-66 receptor; NogoR; NOGORUNQ330/PRO526; reticulon 4 receptor; reticulon-4 receptor; RTN4R
Mass (kDA):
50.708 kDA
Human | |
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Location: | 22q11.21 |
Sequence: | 22; NC_000022.11 (20241415..20268318, complement) |
Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney; not expressed in oligodendrocytes (white matter).
Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Cell projection, axon. Perikaryon. Detected along dendrites and axons, close to synapses, but clearly excluded from synapses.
PMID: 11201742 by Fournier A.E., et al. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration.
PMID: 12426574 by Wong S.T., et al. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein.