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R-spondin-3 Antibodies
AND Rspo3 ELISA kits, R-spondin-3 Proteins
Many biological assays use antibodies to detect R-spondin-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with R-spondin-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop R-spondin-3 antibodies...
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Rspo3 Infographic by Boster Bio
All Rspo3 Products
Product
Figures
Specificity
Applications
Price
Human R-Spondin-3 ELISA Kit PicoKine®
1 Citations 6 Q&As
Human
ELISA
$750
Cat # EK1512
96 wells/kit, with removable strips.
Cat # EK1512
96 wells/kit, with removable strips.
Mouse
ELISA
$750
Cat # EK1525
96 wells/kit, with removable strips.
Cat # EK1525
96 wells/kit, with removable strips.
Human, Mouse, Rat
IHC
$523
Cat # M05387
100 µl
Cat # M05387
100 µl
Human, Mouse, Rat
IHC, WB
$523
Cat # M05387-1
100 µl
Cat # M05387-1
100 µl
Rspo3 Overview
Facts about R-spondin-3.
R-spondin-3 (Rspo3)
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis (PubMed:16543246, PubMed:21693646, PubMed:26766444). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors which are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.
Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Rspo3 |
| Uniprot: | Q2TJ95 |
| Entrez: | 72780 |
Family
| Belongs to: |
|---|
| R-spondin family |
Alternative Names
Cristin 1; CRISTIN1; FLJ14440; hPWTSR; hRspo3; Protein with TSP type-1 repeat; PWTSR; Roof plate-specific spondin-3; RSPO3; R-spondin 3 homolog (Xenopus laevis); RSpondin 3; R-Spondin 3; R-spondin-3; Thrombospondin type-1 domain-containing protein 2; thrombospondin, type I, domain containing 2; THSD2
Molecular Weight
Mass (kDA):
31.454 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 10|10 A4 |
| Sequence: | 10; |
Tissue Specificity
Highly expressed in endothelial cells (PubMed:26766444).
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Fracture
- Mammary Neoplasms
- Mammary Neoplasms, Experimental
- Cell Transformation, Neoplastic
- Leukemia
- Fracture Of First Cervical Vertebra
- Secondary Malignant Neoplasm
- Malignant Neoplasm Of Breast
- Colonic Neoplasms
- Malignant Tumor Of Colon
Pathways
- Endocytosis
- Clathrin-mediated Endocytosis
- Sprouting Angiogenesis
- Osteoclast Differentiation
- Gastrulation
- Cell Proliferation
- Cell Cycle Checkpoint
- Cartilage Morphogenesis
- Sex Determination
- Ossification
- Vasculogenesis
- Limb Development
- Methylation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Rspo3
bosterbio.com/bosterbio-gene-info-cards/Rspo3
References
PMID: 16543246 by Nam J.-S., et al. Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.
PMID: 15469841 by Kazanskaya O., et al. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis.
1 Publications of Boster R-spondin-3 Antibodies & ELISA Kits
- PubMed ID: 10.1007/s00404-019-05126-8, Wnt signaling pathway in early- and late-onset preeclampsia: evaluation with Dic...
*More publications can be found for each product on its corresponding product page