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- Table of Contents
Facts about E3 ubiquitin-protein ligase RNF125.
Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934).
Human | |
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Gene Name: | RNF125 |
Uniprot: | Q96EQ8 |
Entrez: | 54941 |
Belongs to: |
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No superfamily |
E3 ubiquitin-protein ligase RNF125; EC 6.3.2.-; FLJ20456; MGC21737; ring finger protein 125TRAC1; T-cell RING activation protein 1; T-cell ring protein identified in activation screen; TRAC-1
Mass (kDA):
26.454 kDA
Human | |
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Location: | 18q12.1 |
Sequence: | 18; NC_000018.10 (32018585..32090756) |
Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4(+) and CD8(+) T-cells, suggesting that it is preferentially confined to T-cells.
Golgi apparatus membrane; Lipid-anchor. Shows a reticular staining pattern within the cell and is probably expressed at other intracellular membranes in addition to the Golgi membrane. Not detected at the plasma membrane.
PMID: 12974981 by Chu P., et al. Systematic identification of regulatory proteins critical for T-cell activation.
PMID: 15843525 by Zhao H., et al. A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation.