Retinol dehydrogenase 5 Antibodies

AND RDH5 ELISA kits, Retinol dehydrogenase 5 Proteins

Many biological assays use antibodies to detect Retinol dehydrogenase 5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Retinol dehydrogenase 5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Retinol dehydrogenase 5 antibodies...

We validate the specificity of these antibodies to Retinol dehydrogenase 5 by testing them on tissues known to express RDH5 positively and negatively. Browse below to find the RDH5 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RDH5 Infographic by Boster Bio

All RDH5 Products

Product

Figures

Specificity

Applications

Price

Anti-11-cis retinol dehydrogenase RDH5 Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A04955
100ul

RDH5 (NM_002905) Human Over-expression Lysate

Human

$628
Cat # LS005959
100 µg

RDH5 Overview

Facts about Retinol dehydrogenase 5.

RDH5 3D structure. Source: alphafold

Retinol dehydrogenase 5 (RDH5)

Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all- trans-retinol.

Active in the presence of NAD as cofactor but not in the presence of NADP. .

Gene Information

Human
Gene Name:	RDH5
Uniprot:	Q92781
Entrez:	5959

Family

Belongs to:

short-chain dehydrogenases/reductases (SDR) family

Alternative Names

11-cis RDH; 11-cis retinol dehydrogenase; 9,9-cis-retinol specific dehydrogenase; EC 1.1.1; EC 1.1.1.105; FLJ39337; FLJ97089; HSD17B; RDH1; retinol dehydrogenase 1; retinol dehydrogenase 5 (11-cis and 9-cis); retinol dehydrogenase 5 (11-cis/9-cis); SDR9C5; short chain dehydrogenase/reductase family 9C, member 5

Molecular Weight

Mass (kDA):
34.979 kDA

Genomic Context


Human

Location:	12q13.2
Sequence:	12; NC_000012.12 (55720393..55724742)

Tissue Specificity

Abundant in the retinal pigment epithelium. Expressed at high levels in mammary tissue, kidney and testis, and at lower levels in liver, heart, adrenal gland, lung, pancreas and skeletal muscle.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein; Lumenal side.

Diseases

Pigmentary Retinal Dystrophy
Night Blindness
Blind Vision
Retinal Degeneration
Dystrophy
Retinal Diseases
Retinitis Pigmentosa
Retinal Dystrophies
Eye Diseases, Hereditary
Age Related Macular Degeneration
Adenomatous Polyposis Coli
Congenital Stationary Night Blindness

Neoplasms
Chimera Disorder
Atrophy
Myopia
Congenital Night Blindness
Hemeralopia

Pathways

Regeneration
Transport
Localization
Cell Death
Pathogenesis
Light Absorption

PTMs

Oxidation

Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RDH5

References

PMID: 8884265 by Simon A., et al. Primary structure of human 11-cis retinol dehydrogenase and organization and chromosomal localization of the corresponding gene.

PMID: 9115228 by Mertz J.R., et al. Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis- retinoic acid formation.