This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
DNAJB6 Antibodies
AND DNAJB6 ELISA kits, DNAJB6 Proteins
Many biological assays use antibodies to detect DNAJB6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNAJB6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNAJB6 antibodies...
Previous: CCN4
Next: AP1M2
DNAJB6 Infographic by Boster Bio
All DNAJB6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M03290
100 µl
Cat # M03290
100 µl
DNAJB6 Overview
Facts about DnaJ homolog subfamily B member 6.
DnaJ homolog subfamily B member 6 (DNAJB6)
Plays an indispensable function in the business of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins such as huntingtin.
Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation.
Gene Information
| Human | |
|---|---|
| Gene Name: | DNAJB6 |
| Uniprot: | O75190 |
| Entrez: | 10049 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DJ4; DKFZp566D0824; DnaJ (Hsp40) homolog, subfamily B, member 6; dnaJ homolog subfamily B member 6; DnaJ; DnaJ-like 2 protein; FLJ42837; Heat shock protein J2; HHDJ1; HSJ2; HSJ-2; MGC1152; MRJMGC117297; MSJ1; MSJ-1
Molecular Weight
Mass (kDA):
36.087 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q36.3 |
| Sequence: | 7; NC_000007.14 (157337004..157417439) |
Tissue Specificity
Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus.
Subcellular Localizations
Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Melanoma
- Neoplasms
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Dystrophy
- Neurodegenerative Disorders
- Huntington Disease
- Muscular Dystrophy
- Mammary Neoplasms
- Parkinson Disease
Interacting Proteins
- BRMS1
- DYSF
- KRT18
- MLF1
- MLF2
- SGCG
Pathways
- Localization
- Transport
- Nuclear Import
- Cell Adhesion
- Nuclear Transport
- Cell Cycle
- Pathogenesis
- Eye Pigmentation
- Proteolysis
- Pigmentation
- Response To Heat
- Cell Division
- Interphase
PTMs
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNAJB6
bosterbio.com/bosterbio-gene-info-cards/DNAJB6
References
PMID: 9915854 by Pei L.; Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells.
PMID: 11896048 by Chuang J.-Z., et al. Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently.