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- Table of Contents
Facts about Protein CBFA2T1.
Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity).
Human | |
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Gene Name: | RUNX1T1 |
Uniprot: | Q06455 |
Entrez: | 862 |
Belongs to: |
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CBFA2T family |
AML1T1protein CBFA2T1; CBFA2T1Cyclin-D-related protein; CDRMGC2796; core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclinD-related; DKFZp564B213; Eight twenty one protein; ETOFLJ33145; MTG8acute myelogenous leukemia 1 translocation 1, cyclin-D related; Protein ETO; Protein MTG8; runt-related transcription factor 1; translocated to, 1 (cyclin D-related); Zinc finger MYND domain-containing protein 2; ZMYND2myeloid translocation gene on 8q22
Mass (kDA):
67.566 kDA
Human | |
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Location: | 8q21.3 |
Sequence: | 8; NC_000008.11 (91954967..92103451, complement) |
Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.
Nucleus. Colocalizes with ATN1 in discrete nuclear dots.
PMID: 8334990 by Miyoshi H., et al. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript.
PMID: 9661669 by Wolford J.K., et al. Structure and expression of the human MTG8/ETO gene.