Protein CBFA2T3 Antibodies

AND CBFA2T3 ELISA kits, Protein CBFA2T3 Proteins

Many biological assays use antibodies to detect Protein CBFA2T3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein CBFA2T3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein CBFA2T3 antibodies...

We validate the specificity of these antibodies to Protein CBFA2T3 by testing them on tissues known to express CBFA2T3 positively and negatively. Browse below to find the CBFA2T3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CBFA2T3 Infographic by Boster Bio

All CBFA2T3 Products

Product

Figures

Specificity

Applications

Price

Anti-MTG16 Antibody

3 Q&As

Human, Mouse

ELISA, IHC-P, IF (paraffin)

$335
Cat # A30478
100ul

Anti-Protein CBFA2T3 CBFA2T3 Antibody

Human, Mouse, Rat

$405
Cat # A03435
100ul

CBFA2T3 (NM_005187) Human Over-expression Lysate

Human

$960
Cat # LS000863
100 µg

CBFA2T3 Overview

Facts about Protein CBFA2T3.

CBFA2T3 3D structure. Source: alphafold

Protein CBFA2T3 (CBFA2T3)

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of additional corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453).

Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097).

Gene Information

Human
Gene Name:	CBFA2T3
Uniprot:	O75081
Entrez:	863

Family

Belongs to:

CBFA2T family

Alternative Names

core-binding factor, runt domain, alpha subunit 2; translocated to, 3; hMTG16; MTG16ETO2; MTG8-related protein 2; MTGR2MTG8-related gene 2; Myeloid translocation gene on chromosome 16 protein; protein CBFA2T3; Zinc finger MYND domain-containing protein 4; ZMYND4myeloid translocation gene 8 and 16b

Molecular Weight

Mass (kDA):
71.192 kDA

Genomic Context


Human

Location:	16q24.3
Sequence:	16; NC_000016.10 (88874858..88977207, complement)

Tissue Specificity

Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).

Subcellular Localizations

[Isoform 1]: Nucleus, nucleolus. The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.; [Isoform 2]: Nucleus, nucleoplasm. Golgi apparatus membrane.