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- Table of Contents
Facts about RNA transcription, translation and transport factor protein.
May be required for RNA transport (PubMed:24608264). .
Human | |
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Gene Name: | RTRAF |
Uniprot: | Q9Y224 |
Entrez: | 51637 |
Belongs to: |
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RTRAF family |
RNA transcription, translation and transport factor protein
Mass (kDA):
28.068 kDA
Human | |
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Location: | 14q22.1 |
Sequence: | 14; NC_000014.9 (51989546..52010694) |
Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors.
Nucleus. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. May localize at the centrosome during mitosis (PubMed:15147888). Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264).; Nucleus. Cytoplasm. (Microbial infection) Following influenza A virus (IAV) infection, included in influenza A virions via its association with packaged viral ribonucleoproteins (vRNP) in the nucleus and cytoplasm (PubMed
PMID: 11507205 by Huarte M., et al. PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators.
PMID: 15147888 by Howng S.-L., et al. A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors.