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SF3B6 Antibodies
AND SF3B6 ELISA kits, SF3B6 Proteins
Many biological assays use antibodies to detect SF3B6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SF3B6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SF3B6 antibodies...
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SF3B6 Infographic by Boster Bio
All SF3B6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M10990
100 µl
Cat # M10990
100 µl
SF3B6 Overview
Facts about Splicing factor 3B subunit 6.
Splicing factor 3B subunit 6 (SF3B6)
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (PubMed:12234937).
Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (PubMed:16432215). Enters the spliceosome and associates with the pre-mRNA branch website as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively (PubMed:16432215).
Gene Information
| Human | |
|---|---|
| Gene Name: | SF3B6 |
| Uniprot: | Q9Y3B4 |
| Entrez: | 51639 |
Family
| Belongs to: |
|---|
| SF3B6 family |
Alternative Names
Splicing factor 3B subunit 6
Molecular Weight
Mass (kDA):
14.585 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p23.3 |
| Sequence: | 2; NC_000002.12 (24067586..24076326, complement) |
Subcellular Localizations
Nucleus.
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SF3B6
bosterbio.com/bosterbio-gene-info-cards/SF3B6
References
PMID: 11500380 by Will C.L., et al. A novel U2 and U11/U12 snRNP protein that associates with the pre- mRNA branch site.
PMID: 12234937 by Will C.L., et al. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.