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Facts about Reticulon-4 receptor.
Intracellular signaling cascades are triggered through the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200).
Human | |
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Gene Name: | RTN4R |
Uniprot: | Q9BZR6 |
Entrez: | 65078 |
Belongs to: |
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Nogo receptor family |
NgR; NgR1; Nogo R; Nogo receptor; Nogo-66 receptor; NogoR; NOGORUNQ330/PRO526; reticulon 4 receptor; reticulon-4 receptor; RTN4R
Mass (kDA):
50.708 kDA
Human | |
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Location: | 22q11.21 |
Sequence: | 22; NC_000022.11 (20241415..20268318, complement) |
Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney; not expressed in oligodendrocytes (white matter).
Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Cell projection, axon. Perikaryon. Detected along dendrites and axons, close to synapses, but clearly excluded from synapses.
Are you curious about Steven Boster’s life? Learn more about Steven Boster's family and his history. You might also want to know more about his career. In this Boster bio, you'll find some useful information about His work and family. Continue reading to learn more about this pioneering inventor. You'll be pleased you did. You can contact me with any questions. I'm happy answer any questions you might be having!
This page will provide information about Steven Boster’s past. You can obtain Steve Boster’s public information, including his current address, previous addresses, mobile and email details, and even his past addresses. You can also view his known relatives. You can filter your results by age and state to find out exactly who he was related to. To get started, sign up for an account. This will allow for you to search public data for any person, even Steve Boster.
Steve Boster was a Joliet, IL native, who was born on May 29, 1920. He died from COVID-19 on June 6, 2022. He was an army veteran and managed retail sales for many years. He was also a member of Concordia Hall in Staunton, VA. In addition to his son Jonathan, Steven is survived by his sister Tammy, four brothers, and numerous nieces and nephews. Steven Boster's extended family is large, and he is fondly remembered by many of his friends.
His work with the RTN4R marker led him to identify a rare variation of RTN4, a genetic that regulates the structure, function, and organization of neural networks. This gene is located along chromosome 23q11.2, a known area of schizophrenia. Researchers focused their search for rare variants, mutations that have a significant impact upon the protein. Researchers discovered R292H, a single mutation that changed an amino acid from Argonine to Histidine in schizophrenia patients.
Further research on RTN4R suggests that it plays a significant role in synaptic stability and elimination. It is also believed that synaptic plasticity is controlled by the Rtn4r–RhoA signaling pathway. This scientist's work has opened up new research avenues on this gene. He focuses his attention on the role of the Rtn4R gene in synaptic removal.
PMID: 11201742 by Fournier A.E., et al. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration.
PMID: 12426574 by Wong S.T., et al. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein.