RTCA Antibodies

AND RTCA ELISA kits, RTCA Proteins

Many biological assays use antibodies to detect RTCA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RTCA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RTCA antibodies...

We validate the specificity of these antibodies to RTCA by testing them on tissues known to express RTCA positively and negatively. Browse below to find the RTCA antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RTCA Infographic by Boster Bio

All RTCA Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-RTCD1 Antibody

1 Q&As

Human, Mouse, Rat

ELISA, IHC-P, WB, IF (paraffin)

$335
Cat # A30754
100ul

Anti-RTCD1 RTCA Antibody

Human, Rat

IHC, WB

$405
Cat # A07570
100ul

Anti-RTCD1/RTCA Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A07570-1
100 μg/vial

Human RTCA Recombinant Protein

SDS-PAGE

$250
Cat # PROTO00442
Starting from 4ug

Anti-RTCA Antibody Picoband®

Human, Mouse, Rat

ELISA, WB

$370
Cat # A07570-2
100 µg/vial

RTCA Overview

Facts about RNA 3'-terminal phosphate cyclase.

RTCA 3D structure. Source: alphafold

RNA 3'-terminal phosphate cyclase (RTCA)

Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of this enzyme occurs in 3 steps: (A) adenylation of this enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A; (C) and assault of the adjacent 2'-hydroxyl on the 3'- phosphorus at the diester linkage to generate the cyclic end product.

The biological role of this enzyme is unknown but it is very likely to function in some aspects of cellular RNA processing. .

Gene Information

Human
Gene Name:	RTCA
Uniprot:	O00442
Entrez:	8634

Family

Belongs to:

RNA 3'-terminal cyclase family

Alternative Names

phosphate cyclase; RNA 3'-terminal phosphate cyclase; RNA cyclase; RNA terminal phosphate cyclase domain 1; RNA terminal phosphate cyclase domain-containing protein 1; RNA-3'-phosphate cyclase; RPC1; RPCEC 6.5.1.4; RTC domain containing 1; RTC domain-containing protein 1; RTC1

Molecular Weight

Mass (kDA):
39.337 kDA

Genomic Context


Human

Location:	1p21.2
Sequence:	1; NC_000001.11 (100266158..100292769)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus, nucleoplasm.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Lung
Influenza
Cardiac Arrhythmia
Influenza Due To Influenza A Virus Subtype H1n1
Malignant Neoplasm Of Breast
Exudative Age-related Macular Degeneration
Age Related Macular Degeneration
Tumor Angiogenesis
Neoplasms
Pathologic Neovascularization
Cell Invasion

Cytopathogenic Effect, Viral
Non-small Cell Lung Carcinoma
Encephalitis, St. Louis
Palmar-plantar Erythrodysesthesia Syndrome
Malignant Tumor Of Cervix
Torsades De Pointes
Carcinoma

Pathways

Cell Growth
Cell Proliferation
Reductive Tricarboxylic Acid Cycle
Cytolysis
Cell Migration
Tricarboxylic Acid Cycle
Induction Of Apoptosis
Tube Formation
Angiogenesis
Rna Repair
Immune Response

Proteolysis
Localization
Light Absorption
Notch Signaling Pathway
Dna Replication
Pathogenesis

PTMs

Cleavage
Phosphorylation
Carboxylation

Reduction
Decarboxylation
Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RTCA

References

PMID: 9184239 by Genschik P., et al. The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea.

PMID: 2199762 by Filipowicz W., et al. RNA 3'-terminal phosphate cyclase from HeLa cells.