RRM2B Antibodies

AND RRM2B ELISA kits, RRM2B Proteins

Many biological assays use antibodies to detect RRM2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RRM2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RRM2B antibodies...

We validate the specificity of these antibodies to RRM2B by testing them on tissues known to express RRM2B positively and negatively. Browse below to find the RRM2B antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RRM2B Infographic by Boster Bio

All RRM2B Products

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Product

Figures

Specificity

Applications

Price

Anti-p53R2/RRM2B Antibody Picoband®

1 Q&As

Human, Mouse, Rat

$370
Cat # PA2053
100 μg/vial

Anti-RRM2B p53R2 Antibody

6 Q&As

Human

ELISA, WB

$629
Cat # A03055
100ug

Anti-p53R2 RRM2B Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A03055-1
0.1 mg

p53R2 (RRM2B) (NM_015713) Human Recombinant Protein

$813
Cat # PROTQ7LG56
20 µg

RRM2B Overview

Facts about Ribonucleoside-diphosphate reductase subunit M2 B.

RRM2B 3D structure. Source: alphafold

Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)

Plays a pivotal role in cell survival by fixing damaged DNA at a p53/TP53-dependent method. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2.

Includes an iron-tyrosyl free radical center needed for catalysis. Types an active ribonucleotide reductase (RNR) complicated with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.

Gene Information

Human
Gene Name:	RRM2B
Uniprot:	Q7LG56
Entrez:	50484

Family

Belongs to:

ribonucleoside diphosphate reductase small chain family

Alternative Names

EC 1.17.4.1; MGC102856; MGC42116; MTDPS8A; MTDPS8B; p53-inducible ribonucleotide reductase small subunit 2 homolog; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2; P53R2DKFZp686M05248; PEOA5; ribonucleoside-diphosphate reductase subunit M2 B; ribonucleotide reductase M2 B (TP53 inducible); RRM2B; TP53-inducible ribonucleotide reductase M2 B

Molecular Weight

Mass (kDA):
40.737 kDA

Genomic Context


Human

Location:	8q22.3
Sequence:	8; NC_000008.11 (102204501..102238961, complement)

Tissue Specificity

Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma.

Subcellular Localizations

Cytoplasm. Nucleus. Translocates from cytoplasm to nucleus in response to DNA damage.

Diseases

Malignant Neoplasms
Neoplasms
Mitochondrial Diseases
Mitochondrial Dna Depletion
Carcinoma
Chronic Progressive External Ophthalmoplegia
External Ophthalmoplegia
Ophthalmoplegia
Dysmyelopoietic Syndromes
Malignant Squamous Cell Neoplasm
Neoplasm Metastasis
Myopathy
Cell Transformation, Neoplastic

Mitochondrial Neurogastrointestinal Encephalopathy Syndrome
Esophageal Neoplasms
Adenocarcinoma
Cell Invasion
Mitochondrial Encephalomyopathies
Muscle Hypotonia
Malignant Neoplasm Of Lung

Interacting Proteins

ATM
MDM2
ORC4
RNF41

Pathways

Dna Repair
Cell Cycle
Dna Replication
Mitochondrial Dna Replication
Oxidative Phosphorylation
Cell Cycle Arrest
Cell Death
S Phase
Response To Uv
Transport
Cell Migration
Mitosis
Localization

Pathogenesis
Cell Cycle Checkpoint
Dna Hypomethylation
Electron Transport
Electron Transport Chain
Response To Oxidative Stress
Cell Division

PTMs

Phosphorylation
Methylation

Dephosphorylation
Ubiquitination

Research Areas

Apoptosis
Checkpoint signaling
DNA Double Strand Break Repair
DNA Repair
Hypoxia

Modulation of DNA Pools

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RRM2B

References

PMID: 10716435 by Tanaka H., et al. A ribonucleotide reductase gene involved in a p53-dependent cell- cycle checkpoint for DNA damage.

PMID: 11517226 by Guittet O., et al. Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells.