SMARCAL1 Antibodies

AND SMARCAL1 ELISA kits, SMARCAL1 Proteins

Many biological assays use antibodies to detect SMARCAL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMARCAL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMARCAL1 antibodies...

We validate the specificity of these antibodies to SMARCAL1 by testing them on tissues known to express SMARCAL1 positively and negatively. Browse below to find the SMARCAL1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SMARCAL1 Infographic by Boster Bio

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Anti-SmarcAL1 Antibody

6 Q&As

Human

ELISA, WB

$629
Cat # A03383
100ug

SMARCAL1 Overview

Facts about SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1.

SMARCAL1 3D structure. Source: alphafold

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (SMARCAL1)

ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles which are stably bound by replication protein A (RPA).

Acts through the genome to reanneal stably unwound DNA, performing the reverse reaction of several enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.

Gene Information

Human
Gene Name:	SMARCAL1
Uniprot:	Q9NZC9
Entrez:	50485

Family

Belongs to:

SNF2/RAD54 helicase family

Alternative Names

ATP-driven annealing helicase; EC 3.6.1; EC 3.6.4.-; HARPSWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A-like protein 1; HepA-related protein; HHARP; SIOD; SMARCA-like protein 1; subfamily a-like 1; Sucrose nonfermenting protein 2-like 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin

Molecular Weight

Mass (kDA):
105.938 kDA

Genomic Context


Human

Location:	2q35
Sequence:	2; NC_000002.12 (216412484..216483053)

Tissue Specificity

Ubiquitously expressed, with high levels in testis.

Subcellular Localizations

Nucleus. Recruited to damaged DNA regions.

Diseases

Dysplasia
Immunologic Deficiency Syndromes
Osteochondrodysplasias
Nephrotic Syndrome
Spondyloepiphyseal Dysplasia
Multisystem Disorder
Focal Glomerulosclerosis
Bone Diseases, Developmental
Glomerulosclerosis (disorder)
Segmental Glomerulosclerosis
Kidney Failure
Pulmonary Embolism

Dwarfism
T-lymphocyte Immunodeficiency
Arteriosclerosis
Genomic Instability
Kidney Failure, Chronic
Kidney Diseases

Interacting Proteins

RPA2

Pathways

Chromatin Remodeling
Dna Replication
Dna Repair
Cell Cycle
Hypersensitivity
Localization
Pathogenesis
Atp-dependent Chromatin Remodeling
Cell Proliferation
Gene Silencing
Mitosis
Brain Development
Proteolysis

Regulation Of Gene Expression
Chromosome Segregation
Double-strand Break Repair
Glomerular Filtration
Cell Cycle Arrest
Methylation
S Phase

PTMs

Phosphorylation
Biotinylation

Deacetylation
Cleavage

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMARCAL1

References

PMID: 10857751 by Coleman M.A., et al. Cloning and characterization of HARP/SMARCAL1: a prokaryotic HepA- related SNF2 helicase protein from human and mouse.

PMID: 11799392 by Boerkoel C.F., et al. Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno- osseous dysplasia.