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- Table of Contents
Facts about Ribosomal protein S6 kinase alpha-5.
Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, partners in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at'Ser-276' during oxidative stress (PubMed:12628924).
Human | |
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Gene Name: | RPS6KA5 |
Uniprot: | O75582 |
Entrez: | 9252 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.11; MGC1911,90 kDa ribosomal protein S6 kinase 5; MSK1; MSK1EC 2.7.11.1; MSPK1; Nuclear mitogen- and stress-activated protein kinase 1; ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kD, polypeptide 5; ribosomal protein S6 kinase, 90kDa, polypeptide 5; RLPK; RPS6KA5; RSKL; RSK-like protein kinase; S6K-alpha-5
Mass (kDA):
89.865 kDA
Human | |
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Location: | 14q32.11 |
Sequence: | 14; NC_000014.9 (90847861..91060649, complement) |
Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.
Nucleus. Cytoplasm. Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid.
PMID: 9687510 by Deak M., et al. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.
PMID: 9873047 by New L., et al. Cloning and characterization of RLPK, a novel RSK-related protein kinase.