This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Numb-like protein.
Not required for the proliferation of neural progenitor cells prior to the onset of embryonic neurogenesis. Also required postnatally from the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity.
Human | |
---|---|
Gene Name: | NUMBL |
Uniprot: | Q9Y6R0 |
Entrez: | 9253 |
Belongs to: |
---|
No superfamily |
CAG3A; CTG3a; numb (Drosophila) homolog-like; numb homolog (Drosophila)-like; numb homolog-like; numb-like protein; NUMBLIKE; NUMB-R; Numb-related protein; NUMBRNBL; TNRC23
Mass (kDA):
64.891 kDA
Human | |
---|---|
Location: | 19q13.2 |
Sequence: | 19; NC_000019.10 (40665905..40690651, complement) |
Cytoplasm. Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
PMID: 9303539 by Salcini A.E., et al. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.
PMID: 18299187 by Ma Q., et al. NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation.