Renalase (RNLS)

Catalyzes the oxidation of the abundant 1,2- dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta- NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates vascular function and systemic blood pressure.

Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal connection to the increased plasma catecholamine and heightened cardiovascular risk. High levels of catecholamines trigger plasma renalase and promotes its secretion and synthesis.