E3 ubiquitin-protein ligase RNF31 (RNF31)

E3 ubiquitin-protein ligase component of this LUBAC complicated which conjugates linear ('Met-1'-connected ) polyubiquitin chains to substrates and plays an integral role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). LUBAC conjugates linear polyubiquitin into IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684).

Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited into the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC parts by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin into IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237).