RNF26 Antibodies

AND RNF26 ELISA kits, RNF26 Proteins

Many biological assays use antibodies to detect RNF26, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNF26 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNF26 antibodies...

We validate the specificity of these antibodies to RNF26 by testing them on tissues known to express RNF26 positively and negatively. Browse below to find the RNF26 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RNF26 Infographic by Boster Bio

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Anti-RNF26 Antibody

Human, Rat

ELISA, WB

$449
Cat # A15996
0.1 mg

RNF26 Overview

Facts about E3 ubiquitin-protein ligase RNF26.

RNF26 3D structure. Source: alphafold

E3 ubiquitin-protein ligase RNF26 (RNF26)

E3 ubiquitin-protein ligase that plays a key role in endosome business by keeping vesicles in the perinuclear cloud (PubMed:27368102). Acts as a stage for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 (PubMed:27368102).

Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear area and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379).

Gene Information

Human
Gene Name:	RNF26
Uniprot:	Q9BY78
Entrez:	79102

Family

Belongs to:

No superfamily

Alternative Names

MGC2642; ring finger protein 26; ring finger protein with leucine zipper

Molecular Weight

Mass (kDA):
47.737 kDA

Genomic Context


Human

Location:	11q23.3
Sequence:	11; NC_000011.10 (119334527..119337309)

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Neuroblastoma
Malignant Neoplasms
Neoplasms
Carcinogenesis
Malignant Neoplasm Of Stomach
Cholangiocarcinoma
Cell Invasion
Stomach Neoplasms
Adenocarcinoma
Mutation Abnormality
Malignant Squamous Cell Neoplasm
Hematologic Neoplasms
Melanoma

Uterine Cervical Neoplasm
Malignant Tumor Of Colon
Malignant Paraganglionic Neoplasm
Teratocarcinoma
Malignant Tumor Of Cervix
Acute Promyelocytic Leukemia
Leukemia

Interacting Proteins

INCA1

Pathways

Localization
Chromosome Segregation

PTMs

Ubiquitination

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNF26

References

PMID: 11352657 by Katoh M.; Molecular cloning and characterization of RNF26 on human chromosome 11q23 region, encoding a novel RING finger protein with leucine zipper.

PMID: 21750715 by Zhang F., et al. The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co- factor for its antiproliferative effects.