RNF216 Antibodies

AND RNF216 ELISA kits, RNF216 Proteins

Many biological assays use antibodies to detect RNF216, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNF216 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNF216 antibodies...

We validate the specificity of these antibodies to RNF216 by testing them on tissues known to express RNF216 positively and negatively. Browse below to find the RNF216 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RNF216 Infographic by Boster Bio

All RNF216 Products

Product

Figures

Specificity

Applications

Price

Anti-TRIAD3A RNF216 Antibody

Human, Mouse

ELISA, IF, IHC-P, WB

$449
Cat # A05841
0.1 mg

TRIAD3 (RNF216) (NM_207116) Human Over-expression Lysate

Human

$628
Cat # LS054476
100 µg

Anti-RNF216 Antibody Picoband™

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A05841-1
100 µg/vial

RNF216 Overview

Facts about E3 ubiquitin-protein ligase RNF216.

RNF216 3D structure. Source: alphafold

E3 ubiquitin-protein ligase RNF216 (RNF216)

Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9.

Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production.

Gene Information

Human
Gene Name:	RNF216
Uniprot:	Q9NWF9
Entrez:	54476

Family

Belongs to:

No superfamily

Alternative Names

EC 6.3.2.-; ring finger protein 216Ubiquitin-conjugating enzyme 7-interacting protein 1; Triad domain-containing protein 3; TRIAD3Zinc finger protein inhibiting NF-kappa-B; U7I1; UBCE7IP1ubiquitin conjugating enzyme 7 interacting protein 1; ZINE3 ubiquitin-protein ligase RNF216

Molecular Weight

Mass (kDA):
99.406 kDA

Genomic Context


Human

Location:	7p22.1
Sequence:	7; NC_000007.14 (5620047..5781721, complement)

Tissue Specificity

Ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes.

Subcellular Localizations

Cytoplasm.

Diseases

Innate Immune Response
Hiv Infections
Malignant Neoplasm Of Prostate
Neoplasm Metastasis
Hereditary Diseases
Liver Failure
Neoplasm Invasiveness
Immunologic Deficiency Syndromes
Virus Diseases
Prostatic Neoplasms

Malignant Neoplasms
Obesity
Hepatolenticular Degeneration
Inflammation
Rna Virus Infections

Pathways

Innate Immune Response
Immune Response
Neuroprotection
Regeneration
Cell Activation
Cytokine Production
Reverse Transcription
Tissue Regeneration

Endocytosis
Localization
Excretion

PTMs

Ubiquitination

Reduction

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNF216

References

PMID: 11854271 by Chen D., et al. A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1- induced NF-kappa B activation.

PMID: 15107846 by Chuang T.-H., et al. Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.