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- Table of Contents
Facts about E3 ubiquitin-protein ligase BRE1A.
It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory.
Human | |
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Gene Name: | RNF20 |
Uniprot: | Q5VTR2 |
Entrez: | 56254 |
Belongs to: |
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BRE1 family |
BRE1 E3 ubiquitin ligase homolog; BRE1; BRE1-A; BRE1AMGC129667; E3 ubiquitin-protein ligase BRE1A; EC 6.3.2; EC 6.3.2.-; FLJ11189; FLJ20382; hBRE1MGC129668; homolog of S. cerevisiae BRE1; KAIA2779; ring finger protein 20KIAA2779
Mass (kDA):
113.662 kDA
Human | |
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Location: | 9q31.1 |
Sequence: | 9; NC_000009.12 (101533853..101563344) |
Expressed in the normal brain and also in malignant gliomas (at protein level).
Nucleus.
PMID: 16307923 by Zhu B., et al. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.
PMID: 16337599 by Kim J., et al. The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions.