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RNF185 Antibodies
AND RNF185 ELISA kits, RNF185 Proteins
Many biological assays use antibodies to detect RNF185, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNF185 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNF185 antibodies...
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RNF185 Overview
Facts about E3 ubiquitin-protein ligase RNF185.
E3 ubiquitin-protein ligase RNF185 (RNF185)
E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693). Acts from the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036).
Protects cells from ER stress-induced apoptosis (PubMed:27485036). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521).
Gene Information
| Human | |
|---|---|
| Gene Name: | RNF185 |
| Uniprot: | Q96GF1 |
| Entrez: | 91445 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BSK65-MONO1; BSK65-MONO2; BSK65-PANC1; BSK65-PANC2; BSK65-TEST1; BSK65-TEST2; BSK65-TEST3; FLJ38628; ring finger protein 185
Molecular Weight
Mass (kDA):
20.459 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q12.2 |
| Sequence: | 22; NC_000022.11 (31160182..31207019) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Diseases
- Clear-cell Metastatic Renal Cell Carcinoma
- Neoplasms
- Benign Neoplasm Of Kidney
- Renal Cell Carcinoma
- Von Hippel-lindau Syndrome
- Kidney Neoplasm
Interacting Proteins
- ARL6IP5
- CMTM5
- RNF5
- TMBIM6
- UBE2D1
- UBE2D2
- UBE2D4
- UBE2E2
- UBE2E3
- YIPF2
Pathways
- Methylation
- Catabolic Process
- Localization
- Autophagy
PTMs
- Methylation
Research Areas
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNF185
bosterbio.com/bosterbio-gene-info-cards/RNF185
References
PMID: 21931693 by Tang F., et al. RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1.
PMID: 24019521 by El Khouri E., et al. RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR).