Rnf168 Antibodies

AND Rnf168 ELISA kits, Rnf168 Proteins

Many biological assays use antibodies to detect Rnf168, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Rnf168 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Rnf168 antibodies...

We validate the specificity of these antibodies to Rnf168 by testing them on tissues known to express Rnf168 positively and negatively. Browse below to find the Rnf168 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Rnf168 Infographic by Boster Bio

All Rnf168 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-RNF168 Picoband® Antibody

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A01224-1
100 μg/vial

Anti-RNF168 Antibody

Human, Mouse

ELISA, WB

$449
Cat # A01224
0.1 mg

RNF168 (NM_152617) Human Over-expression Lysate

Human

$628
Cat # LS165918
100 µg

Rnf168 Overview

Facts about E3 ubiquitin-protein ligase RNF168.

E3 ubiquitin-protein ligase RNF168 (Rnf168)

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination.

Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8- dependent H2A ubiquitination, promoting the creation of'Lys-63'- linked ubiquitin conjugates. This leads to focus ubiquitinated histones H2A and H2AX in DNA lesions to the threshold necessary for recruitment of TP53BP1 and BRCA1.

Gene Information

Mouse
Gene Name:	Rnf168
Uniprot:	Q80XJ2
Entrez:	70238

Family

Belongs to:

RNF168 family

Alternative Names

E3 ubiquitin-protein ligase RNF168; EC 6.3.2; EC 6.3.2.-; FLJ39749; ring finger protein 168FLJ35794; RNF168

Molecular Weight

Mass (kDA):
64.779 kDA

Genomic Context


Mouse

Location:	16\|16 B3
Sequence:	16;

Diseases

Malignant Neoplasms
Genomic Instability
Neoplasms
Immunologic Deficiency Syndromes
Ataxia Telangiectasia
Malignant Neoplasm Of Breast
Ataxia
Cell Transformation, Neoplastic
Telangiectasis
Fanconi Anemia
Premature Aging Syndrome
Chromosome Breakage

Cytogenetic Abnormality
Anemia
Nerve Degeneration
Dna Repair-deficiency Disorders
Learning Disorders
Bone Neoplasms

Pathways

Dna Repair
Cell Cycle
Localization
Double-strand Break Repair
Cell Division
Chromatin Remodeling
Conjugation
Histone Ubiquitination
Aging
V(d)j Recombination
Dna Damage Checkpoint
Mitosis
Dna Replication

Response To Ionizing Radiation
Cell Death
Cell Cycle Checkpoint
Gene Silencing
Immune Response
Spermatogenesis
System Development

PTMs

Phosphorylation
Ubiquitination
Sumoylation
Cleavage

Methylation
Deamination
Deacetylation
Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Rnf168

References

PMID: 20080757 by Ramachandran S., et al. The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination.