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RIOK2 Antibodies
AND RIOK2 ELISA kits, RIOK2 Proteins
Many biological assays use antibodies to detect RIOK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RIOK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RIOK2 antibodies...
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RIOK2 Infographic by Boster Bio
All RIOK2 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse
IF, IHC, WB
$523
Cat # M09743
100 µl
Cat # M09743
100 µl
Human
Flow Cytometry, IHC, WB
$523
Cat # M09743-1
100 µl
Cat # M09743-1
100 µl
RIOK2 Overview
Facts about Serine/threonine-protein kinase RIO2.
Serine/threonine-protein kinase RIO2 (RIOK2)
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm.
Its kinase activity is required for the launch of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of this metaphase-anaphase transition through mitotic progression, and its phosphorylation, probably by PLK1, modulates this function (PubMed:21880710).
Gene Information
| Human | |
|---|---|
| Gene Name: | RIOK2 |
| Uniprot: | Q9BVS4 |
| Entrez: | 55781 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11.1; FLJ11159; RIO kinase 2 (yeast); RIO kinase 2; RIO2; serine/threonine-protein kinase RIO2
Molecular Weight
Mass (kDA):
63.283 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q15 |
| Sequence: | 5; NC_000005.10 (97160867..97183247, complement) |
Subcellular Localizations
Cytoplasm. Exported out of the nucleus via its NES in a XPO1-dependent manner.
Pathways
- Ribosome Biogenesis
PTMs
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RIOK2
bosterbio.com/bosterbio-gene-info-cards/RIOK2
References
PMID: 16037817 by Rouquette J., et al. Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells.
PMID: 19564402 by Zemp I., et al. Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2.