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- Table of Contents
Facts about Synembryn-A.
Involved in regulation of microtubule pulling forces during mitotic motion of chromosomes by stimulating G(I)-alpha protein, potentially leading to release G(I)-alpha-GTP and NuMA proteins in the NuMA-GPSM2-G(I)-alpha-GDP complex (By similarity). Also serves as an activator for G(q)-alpha (GNAQ) protein by boosting the G(q)-coupled receptor-mediated ERK activation.
Human | |
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Gene Name: | RIC8A |
Uniprot: | Q9NPQ8 |
Entrez: | 60626 |
Belongs to: |
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synembryn family |
RIC8; RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans); synembryn; synembryn-A
Mass (kDA):
59.71 kDA
Human | |
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Location: | 11p15.5 |
Sequence: | 11; NC_000011.10 (207511..215175) |
Cytoplasm. Cell membrane. Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity).
PMID: 16629901 by Nishimura A., et al. Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells.