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RHOH Antibodies
AND RHOH ELISA kits, RHOH Proteins
Many biological assays use antibodies to detect RHOH, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RHOH in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RHOH antibodies...
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RHOH Infographic by Boster Bio
All RHOH Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1827
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1827
1 kit, containing one 96-well plate and all necessary reagents
RHOH Overview
Facts about Rho-related GTP-binding protein RhoH.
Rho-related GTP-binding protein RhoH (RHOH)
Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways.
Essential for efficient beta-selection and positive choice by encouraging the ZAP70-dependent phosphorylation of the LAT signalosome through pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and through positive selection.
Gene Information
| Human | |
|---|---|
| Gene Name: | RHOH |
| Uniprot: | Q15669 |
| Entrez: | 399 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
ras homolog gene family, member H; translocation three four
Molecular Weight
Mass (kDA):
21.331 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p14 |
| Sequence: | 4; NC_000004.12 (40191080..40246967) |
Tissue Specificity
Expressed only in hematopoietic cells. Present at very high levels in the thymus, less abundant in the spleen, and least abundant in the bone marrow. Expressed at a higher level in the TH1 subtype of T-helper cells than in the TH2 subpopulation. Expressed in neutrophils under inflammatory conditions, such as cystic fibrosis, ulcerative colitis and appendicitis.
Subcellular Localizations
Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side. Colocalizes together with ZAP70 in the immunological synapse.
Diseases
- Lymphoma
- B-cell Lymphomas
- Leukemia
- Diffuse Large B-cell Lymphoma
- Tissue Adhesions
- Myeloid Leukemia
- Lymphoma, Non-hodgkin
- Neoplasms
- Leukemia, Myelocytic, Acute
- Genomic Instability
- Splenic Neoplasms
- Lymphoma, Follicular
- Chromosomal Translocation
Pathways
- Pathogenesis
- Localization
- Chemotaxis
- Cell Migration
- Cytokinesis
- Cell Proliferation
- Cell Development
- Cell Growth
- Rna Interference
- T Cell Selection
- Immune Response
- Cell Cycle Arrest
- Translation
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RHOH
bosterbio.com/bosterbio-gene-info-cards/RHOH
References
PMID: 7784061 by Dallery E., et al. TTF, a gene encoding a novel small G protein, fuses to the lymphoma- associated LAZ3 gene by t(3;4) chromosomal translocation.
PMID: 11809807 by Li X., et al. The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.