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- Table of Contents
Facts about Regulator of cell cycle RGCC.
May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression in the G2/M transition.
Human | |
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Gene Name: | RGCC |
Uniprot: | Q9H4X1 |
Entrez: | 28984 |
Belongs to: |
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No superfamily |
bA157L14.2; chromosome 13 open reading frame 15; KIAA0564; RGC-32MGC87338; RGC32response gene to complement 32 protein
Mass (kDA):
14.559 kDA
Human | |
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Location: | 13q14.11 |
Sequence: | 13; NC_000013.11 (41457411..41470876) |
Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells. Overexpressed in colon, breast, prostate, bladder, lung, and ovarian cancer tissues.
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase.
PMID: 11687586 by Badea T., et al. RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase.
PMID: 15713436 by Fosbrink M., et al. Overexpression of RGC-32 in colon cancer and other tumors.