Malignant T-cell-amplified sequence 1 (MCTS1)

Anti-oncogene that plays a role in cell cycle regulation; reduces cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases action and CCND1/cyclin D1 protein level, in addition to G1 cyclin/CDK complex formation.

Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes to subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, then altering the mRNA translation profile; up- regulates protein amounts of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels stays constant.