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- Table of Contents
Facts about Malignant T-cell-amplified sequence 1.
Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes to subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, then altering the mRNA translation profile; up- regulates protein amounts of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels stays constant.
Human | |
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Gene Name: | MCTS1 |
Uniprot: | Q9ULC4 |
Entrez: | 28985 |
Belongs to: |
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MCTS1 family |
malignant T cell amplified sequence 1; Malignant T-Cell-Amplified Sequence 1; MCT-1; Multiple Copies T-Cell Malignancies
Mass (kDA):
20.555 kDA
Human | |
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Location: | Xq24 |
Sequence: | X; NC_000023.11 (120604101..120621159) |
Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas.
Cytoplasm. Nuclear relocalization after DNA damage.
PMID: 9766643 by Prosniak M., et al. A novel candidate oncogene, MCT-1, is involved in cell cycle progression.
PMID: 16533400 by Kemmer D., et al. NovelFam3000 -- uncharacterized human protein domains conserved across model organisms.