DNA-binding protein RFX2 Antibodies

AND RFX2 ELISA kits, DNA-binding protein RFX2 Proteins

Many biological assays use antibodies to detect DNA-binding protein RFX2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNA-binding protein RFX2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNA-binding protein RFX2 antibodies...

We validate the specificity of these antibodies to DNA-binding protein RFX2 by testing them on tissues known to express RFX2 positively and negatively. Browse below to find the RFX2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RFX2 Infographic by Boster Bio

All RFX2 Products

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Anti-DNA-binding protein RFX2 RFX2 Antibody

7 Q&As

Human

IHC

$360
Cat # A06709
100 µl

RFX2 (NM_000635) Human Recombinant Protein

$813
Cat # PROTP48378
20 µg

RFX2 Overview

Facts about DNA-binding protein RFX2.

RFX2 3D structure. Source: alphafold

DNA-binding protein RFX2 (RFX2)

Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes needed for the haploid stage during spermiogenesis, like genes required for cilium assembly and function (By similarity).

Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis- specific histone gene HIST1H1T (By similarity).

Gene Information

Human
Gene Name:	RFX2
Uniprot:	P48378
Entrez:	5990

Family

Belongs to:

RFX family

Alternative Names

DNA binding protein RFX2; DNA-binding protein RFX2; FLJ14226; HLA class II regulatory factor RFX2; Regulatory factor X 2; regulatory factor X, 2 (influences HLA class II expression); trans-acting regulatory factor 2

Molecular Weight

Mass (kDA):
79.987 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (5993164..6110601, complement)

Subcellular Localizations

Nucleus. Cytoplasm. Mainly expressed in the nucleus and at lower level in cytoplasm.

Diseases

Malignant Neoplasms
Hepatitis B
Carcinogenesis
Hepatitis
Candidiasis
Oropharyngeal Disorders
Oropharyngeal Candidiasis
Ectopic Pregnancy
Malignant Neoplasm Of Breast
Malignant Neoplasm Of Lung
Carcinoma
Disseminated Candidiasis
Immunologic Deficiency Syndromes

Patient Dependence On
Neoplasms
Cell Invasion
Infective Disorder
Adenocarcinoma
Neuroblastoma
Lung Neoplasms

Interacting Proteins

FOXJ1
RFX6

Pathways

Spermatogenesis
Pachytene
Meiosis
Lateral Inhibition
Cell Differentiation
Rna Interference
Transport
Cell Proliferation
Developmental Process
Neuroendocrine Cell Differentiation
Nodal Signaling Pathway
Neurogenesis
Regulation Of Gene Expression

Virulence
Embryo Development
Methylation
Cell Division
S Phase
Prophase
Cell Growth

PTMs

Biotinylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RFX2

References

PMID: 8289803 by Reith W., et al. RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.

PMID: 10330134 by Iwama A., et al. Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.