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RET Antibodies
AND RET ELISA kits, RET Proteins
Many biological assays use antibodies to detect RET, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RET in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RET antibodies...
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RET Infographic by Boster Bio
All RET Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00293
100 μl
Cat # M00293
100 μl
Human
ELISA
$499
Cat # EK1877
96 wells/kit, with removable strips.
Cat # EK1877
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA
$480
Cat # EKC1499
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1499
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2117
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2117
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2506
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2506
1 kit, containing two 96-well plates and all necessary reagents
RET Overview
Facts about Proto-oncogene tyrosine-protein kinase receptor Ret.
Proto-oncogene tyrosine-protein kinase receptor Ret (RET)
Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1.
Regulates both cell death/survival balance and positional information. Required for the molecular mechanics orchestration during intestine organogenesis; involved in the growth of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major part of the gut- associated lymphoid tissue.
Gene Information
| Human | |
|---|---|
| Gene Name: | RET |
| Uniprot: | P07949 |
| Entrez: | 5979 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CDHF12MTC1; CDHR16; EC 2.7.10; Hirschsprung disease 1; Hirschsprung disease); MEN2A; MEN2B; multiple endocrine neoplasia and medullary thyroid carcinoma 1; ret proto-oncogene; RET transforming sequence; Ret
Molecular Weight
Mass (kDA):
124.319 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q11.21 |
| Sequence: | 10; NC_000010.11 (43077027..43130351) |
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Predominantly located on the plasma membrane. In the presence of SORL1 and GFRA1, directed to endosomes.
Diseases
- Neoplasms
- Carcinoma
- Thyroid Neoplasm
- Malignant Neoplasm Of Thyroid
- Malignant Neoplasms
- Medullary Carcinoma Of Thyroid
- Multiple Endocrine Neoplasia Type 2a
- Multiple Endocrine Neoplasia
- Endocrine Gland Neoplasms
- Carcinoma, Papillary
- Papillary Thyroid Carcinoma
- Hirschsprung Disease
- Pheochromocytoma
Interacting Proteins
- NOTCH2NL
- PLCG1
- Sh2b1
- STAT3
Pathways
- Pathogenesis
- Cell Proliferation
- Localization
- Kidney Development
- Cell Death
- Cell Growth
- Innervation
- Cell Cycle
- Angiogenesis
- Secretion
- Cell Adhesion
- Transport
- Cell Migration
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Glycosylation
- Reduction
- Dephosphorylation
- Ubiquitination
- Biotinylation
- Acetylation
- Gpi Anchoring
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RET
bosterbio.com/bosterbio-gene-info-cards/RET
References
PMID: 2660074 by Takahashi M.; Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence.
PMID: 3078962 by Takahashi M., et al. Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains.