REV3L Antibodies

AND REV3L ELISA kits, REV3L Proteins

Many biological assays use antibodies to detect REV3L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with REV3L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop REV3L antibodies...

We validate the specificity of these antibodies to REV3L by testing them on tissues known to express REV3L positively and negatively. Browse below to find the REV3L antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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REV3L Infographic by Boster Bio

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Anti-DNA pol zeta REV3L Antibody

Human, Mouse

ELISA, IHC

$380
Cat # A04785
100ul

REV3L Overview

Facts about DNA polymerase zeta catalytic subunit.

DNA polymerase zeta catalytic subunit (REV3L)

Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.

Gene Information

Human
Gene Name:	REV3L
Uniprot:	O60673
Entrez:	5980

Family

Belongs to:

DNA polymerase type-B family

Alternative Names

EC 2.7.7; EC 2.7.7.7; hREV3; Protein reversionless 3-like; REV3 (yeast homolog)-like, catalytic subunit of DNA polymerase zeta; REV3-like; REV3-like, catalytic subunit of DNA polymerase zeta (yeast); yeast, homolog-like (polymerase, DNA, zeta)

Molecular Weight

Mass (kDA):
352.776 kDA

Genomic Context


Human

Location:	6q21
Sequence:	6; NC_000006.12 (111299031..111483715, complement)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Cell Transformation, Neoplastic
Genomic Instability
Carcinoma
Fanconi Anemia
Colonic Neoplasms
Glioma
Malignant Tumor Of Colon
Cytogenetic Abnormality
Anemia
Malignant Neoplasm Of Breast
Lymphoma

Mammary Neoplasms
Brain Neoplasms
Chromosomal Translocation
Radiation Injury
Stomach Neoplasms
Instabilities, Chromosomal
Exposure To Ionizing Radiation

Interacting Proteins

MAD2L2

Pathways

Translesion Synthesis
Cell Cycle
Dna Replication
Dna Repair
Mismatch Repair
S Phase
Cell Growth
G2 Phase
Localization
Senescence
Error-prone Translesion Synthesis
Double-strand Break Repair
Cell Cycle Arrest

Gene Conversion
Response To Uv
Recombinational Repair
Chromosome Localization
Cell Proliferation
Somatic Hypermutation Of Immunoglobulin Genes
Somitogenesis

PTMs

Phosphorylation

Ubiquitination

Research Areas

DNA Polymerases
DNA Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/REV3L

References

PMID: 9618506 by Gibbs P.E.M., et al. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta.

PMID: 10102035 by Lin W., et al. A full-length cDNA of hREV3 is predicted to encode DNA polymerase zeta for damage-induced mutagenesis in humans.