REC8 Antibodies

AND REC8 ELISA kits, REC8 Proteins

Many biological assays use antibodies to detect REC8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with REC8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop REC8 antibodies...

We validate the specificity of these antibodies to REC8 by testing them on tissues known to express REC8 positively and negatively. Browse below to find the REC8 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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REC8 Infographic by Boster Bio

All REC8 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-REC8 Antibody

13 Q&As

Human

$360
Cat # A04915
100 µl

Anti-REC8 Antibody Picoband®

Human, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A04915-2
100 μg/vial

REC8 (NM_005132) Human Recombinant Protein

$813
Cat # PROTO95072
20 µg

REC8 (NM_005132) Human Over-expression Lysate

Human

$628
Cat # LS009985
100 µg

REC8 Overview

Facts about Meiotic recombination protein REC8 homolog.

REC8 3D structure. Source: alphafold

Meiotic recombination protein REC8 homolog (REC8)

Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin through anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity).

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Gene Information

Human
Gene Name:	REC8
Uniprot:	O95072
Entrez:	9985

Family

Belongs to:

rad21 family

Alternative Names

Cohesin Rec8p; cohesion rec8p; HR21spB; meiotic recombination and sister chromatid cohesion phosphoprotein of therad21p family; meiotic recombination protein REC8 homolog; meiotic recombination protein REC8-like 1; MGC950; REC8 homolog (yeast); REC8L1human homolog of rad21, S. pombe; REC8-like 1 (yeast); REC8-like 1; Rec8p; recombination and sister chromatid cohesion protein homolog

Molecular Weight

Mass (kDA):
62.614 kDA

Genomic Context


Human

Location:	14q12
Sequence:	14; NC_000014.9 (24171931..24180408)

Tissue Specificity

Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa (at protein level).

Subcellular Localizations

Nucleus. Chromosome. Chromosome, centromere. In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II. Localised to centromeres and spindle poles in endopolyploid tumor cells.

Diseases

Aneuploidy
Infertility
Sterility
Neoplasms
Male Infertility
Cell Invasion
Azoospermia
Chromosome Breakage
Cytogenetic Abnormality
Congenital Abnormality
Polyploidy

Cholangiocarcinoma
Teratoma
Spermatogenesis Arrest
Gastrointestinal Neoplasms
Stromal Neoplasm
Misalignment

Pathways

Meiosis
Chromosome Segregation
Meiosis I
Prophase
Sister Chromatid Cohesion
Mitosis
Anaphase
Metaphase
Meiosis Ii
Localization
Pachytene
Dna Replication
S Phase

Meiotic Chromosome Segregation
Meiotic Prophase I
Cell Division
Cell Cycle
Double-strand Break Repair
Female Meiosis
Diplotene

PTMs

Cleavage
Phosphorylation
Dephosphorylation

Methylation
Demethylation
Ubiquitination

Research Areas

Cell Cycle and Replication
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/REC8

References

PMID: 10207075 by Parisi S., et al. Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans.