RCCD1 Antibodies

AND RCCD1 ELISA kits, RCCD1 Proteins

Many biological assays use antibodies to detect RCCD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RCCD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RCCD1 antibodies...

We validate the specificity of these antibodies to RCCD1 by testing them on tissues known to express RCCD1 positively and negatively. Browse below to find the RCCD1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RCCD1 Infographic by Boster Bio

All RCCD1 Products

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Product

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Specificity

Applications

Price

RCCD1 (NM_001017919) Human Recombinant Protein

$813
Cat # PROTA6NED2
20 µg

RCCD1 (NM_001017919) Human Over-expression Lysate

Human

$628
Cat # LS091433
100 µg

RCCD1 Overview

Facts about RCC1 domain-containing protein 1.

RCCD1 3D structure. Source: alphafold

RCC1 domain-containing protein 1 (RCCD1)

Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated 'Lys-36' (H3K36me2/me3) of histone H3 (PubMed:24981860). Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8 (PubMed:24981860).

Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), possibly through the inhibition of KDM8 (PubMed:28455245).

Gene Information

Human
Gene Name:	RCCD1
Uniprot:	A6NED2
Entrez:	91433

Family

Belongs to:

No superfamily

Alternative Names

MGC14386; RCC1 domain containing 1

Molecular Weight

Mass (kDA):
40.079 kDA

Genomic Context


Human

Location:	15q26.1
Sequence:	15; NC_000015.10 (90954864..90964858)

Subcellular Localizations

Chromosome. Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3).

Diseases

Kidney Calculi
Tissue Damage
Nephrolithiasis

Pathways

Secretion
Cell Death
Necrotic Cell Death
Transport
Translation
Programmed Cell Death

Ion Transport

PTMs

Hydroxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RCCD1

References

PMID: 24981860 by Marcon E., et al. Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.

PMID: 28455245 by Wu J., et al. RCCD1 depletion attenuates TGF-beta-induced EMT and cell migration by stabilizing cytoskeletal microtubules in NSCLC cells.