Histone-binding protein RBBP7 (RBBP7)

Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that's regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism.

These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZHtwo complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. .