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DNA endonuclease RBBP8 Antibodies
AND RBBP8 ELISA kits, DNA endonuclease RBBP8 Proteins
Many biological assays use antibodies to detect DNA endonuclease RBBP8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNA endonuclease RBBP8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNA endonuclease RBBP8 antibodies...
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RBBP8 Infographic by Boster Bio
All RBBP8 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$449
Cat # A02076-1
0.1 mg
Cat # A02076-1
0.1 mg
Human, Mouse
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02076-2
100 µg/vial
Cat # A02076-2
100 µg/vial
RBBP8 Overview
Facts about DNA endonuclease RBBP8.
DNA endonuclease RBBP8 (RBBP8)
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double- strand break (DSB) repair through the homologous recombination (HR) pathway. HR is limited to S and G2 phases of the cell cycle and preferentially repairs DSBs caused by replication fork collapse.
Key determinant of DSB repair pathway option, as it commits cells to HR by preventing classical non-homologous end- joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the creation of ssDNA.
Gene Information
| Human | |
|---|---|
| Gene Name: | RBBP8 |
| Uniprot: | Q99708 |
| Entrez: | 5932 |
Family
| Belongs to: |
|---|
| COM1/SAE2/CtIP family |
Alternative Names
CtBP-interacting protein; CtIP; DNA endonuclease RBBP8; EC 3.1; RBBP-8; retinoblastoma binding protein 8; Retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; RIMSAE2; Sporulation in the absence of SPO11 protein 2 homolog
Molecular Weight
Mass (kDA):
101.942 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q11.2 |
| Sequence: | 18; NC_000018.10 (22914121..23026486) |
Tissue Specificity
Expressed in ER-positive breast cancer lines, but tends to be down-regulated ER-negative cells (at protein level).
Subcellular Localizations
Nucleus. Chromosome. Associates with sites of DNA damage in S/G2 phase (PubMed:10764811, PubMed:25349192). Ubiquitinated RBBP8 binds to chromatin following DNA damage (PubMed:16818604).
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Genomic Instability
- Retinoblastoma
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Ovary
- Ataxia
- Ovarian Neoplasm
- Ataxia Telangiectasia
- Telangiectasis
Interacting Proteins
- BRCA1
- EXD2
- EXO1
- LMO1
- LMO4
- MRE11
- NBN
- PIN1
- PSIP1
- RB1
Pathways
- Cell Cycle
- Dna Repair
- Cell Cycle Checkpoint
- Localization
- Double-strand Break Repair
- S Phase
- Hypersensitivity
- Cell Cycle Arrest
- Dna Damage Checkpoint
- Cell Proliferation
- Dna Replication
- Rna Interference
- Sensitization
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Sumoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RBBP8
bosterbio.com/bosterbio-gene-info-cards/RBBP8
References
PMID: 9721205 by Fusco C., et al. Molecular cloning and characterization of a novel retinoblastoma- binding protein.
PMID: 9535825 by Schaeper U., et al. Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif.