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RBBP6 Antibodies
AND RBBP6 ELISA kits, RBBP6 Proteins
Many biological assays use antibodies to detect RBBP6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RBBP6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RBBP6 antibodies...
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RBBP6 Overview
Facts about E3 ubiquitin-protein ligase RBBP6.
E3 ubiquitin-protein ligase RBBP6 (RBBP6)
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, resulting in its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of this p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may be the negative regulator of p53/TP53, resulting in both apoptosis and cell growth (By similarity).
Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10- dependent way. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 subsequently negatively regulates the expression of MCM10 that has an important role in DNA-replication (PubMed:24726359).
Gene Information
| Human | |
|---|---|
| Gene Name: | RBBP6 |
| Uniprot: | Q7Z6E9 |
| Entrez: | 5930 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
E3 ubiquitin-protein ligase RBBP6; EC 6.3.2.-; MY038; P2PR; P2P-R; p53-associated cellular protein of testis; PACTDKFZp761B2423; Proliferation potential-related protein; Protein P2P-R; RB-binding Q-protein 1; RBQ1; RBQ-1; retinoblastoma binding protein 6; Retinoblastoma-binding protein 6DKFZp686P0638; Retinoblastoma-binding Q protein 1; SNAMA
Molecular Weight
Mass (kDA):
201.564 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p12.1 |
| Sequence: | 16; NC_000016.10 (24539566..24572863) |
Tissue Specificity
Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.
Subcellular Localizations
Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome.
Diseases
- Retinoblastoma
- Malignant Neoplasms
- Neoplasms
- Esophageal Neoplasms
- Carcinoma
- Adenocarcinoma
- Retinal Degeneration
- Myeloid Leukemia, Chronic
- Malignant Neoplasm Of Lung
- Carcinogenesis
- Endoplasmic Reticulum Stress
- Congenital Small Ears
Interacting Proteins
- SRSF7
Pathways
- Mitosis
- Cell Cycle
- Localization
- Translation
- Mrna Processing
- Interphase
- Cell Proliferation
- Induction Of Apoptosis
- Transport
- Developmental Process
- Aging
- Immune Response
- Mesoderm Formation
PTMs
- Ubiquitination
Research Areas
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RBBP6
bosterbio.com/bosterbio-gene-info-cards/RBBP6
References
PMID: 8595913 by Sakai Y., et al. cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene product.
PMID: 12064457 by Gao S., et al. P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity.