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RBBP5 Antibodies
AND RBBP5 ELISA kits, RBBP5 Proteins
Many biological assays use antibodies to detect RBBP5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RBBP5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RBBP5 antibodies...
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RBBP5 Infographic by Boster Bio
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RBBP5 Overview
Facts about Retinoblastoma-binding protein 5.
Retinoblastoma-binding protein 5 (RBBP5)
In embryonic stem cells (ES) cells, plays a vital role in the differentiation potential, especially along the neural lineage, regulating gene induction and H3'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complicated, involved in mono-, di- and trimethylation at'Lys-4' of histone H3.
Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. .
Gene Information
| Human | |
|---|---|
| Gene Name: | RBBP5 |
| Uniprot: | Q15291 |
| Entrez: | 5929 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
RBQ3RBBP-5; retinoblastoma binding protein 5; Retinoblastoma-binding protein RBQ-3; Set1c WD40 repeat protein, homolog; SWD1
Molecular Weight
Mass (kDA):
59.153 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.1 |
| Sequence: | 1; NC_000001.11 (205086142..205122015, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Leukemia
- Neoplasms
- Malignant Neoplasms
- Multiple Endocrine Neoplasia Type 1
- Endocrine Gland Neoplasms
- Glioma
- Multiple Endocrine Neoplasia
- Pituitary Diseases
- Glioblastoma
- Oligodendroglioma
- Fibrolamellar Carcinoma
- Parathyroid Hyperplasia
Interacting Proteins
- ASH2L
- CHD8
- CUL4A
- CXXC1
- KMT2A
- PAXIP1
- SETD1A
- WDR5
Pathways
- Methylation
- Histone Methylation
- Transport
- Histone Modification
- Cell Cycle
- Cell Growth
- Cell Adhesion
- Atp-dependent Chromatin Remodeling
- Gene Silencing
- Stem Cell Differentiation
- Cellular Senescence
- Proteolysis
- Regulation Of Gene Expression
PTMs
- Methylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RBBP5
bosterbio.com/bosterbio-gene-info-cards/RBBP5
References
PMID: 7558034 by Saijo M., et al. Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping.
PMID: 14992727 by Hughes C.M., et al. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.