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- Table of Contents
Facts about Ran-binding protein 9.
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA- 1 and other integrins (PubMed:14722085).
Human | |
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Gene Name: | RANBP9 |
Uniprot: | Q96S59 |
Entrez: | 10048 |
Belongs to: |
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RANBP9/10 family |
BPM90; BPM-L; RAN binding protein 9; Ran Binding Protein in the Microtubule organizing center; ran binding protein, centrosomal; ran-binding protein 9; Ran-binding protein M; RanBP7; RanBP9; RanBPM; RANBPMnovel centrosomal protein RanBPM
Mass (kDA):
77.847 kDA
Human | |
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Location: | 6p23 |
Sequence: | 6; NC_000006.12 (13621498..13711835, complement) |
Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells.
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. The unphosphorylated form is predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane.
PMID: 11470507 by Nishitani H., et al. Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex.
PMID: 9817760 by Nakamura M., et al. When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin.