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RAD17 Antibodies
AND RAD17 ELISA kits, RAD17 Proteins
Many biological assays use antibodies to detect RAD17, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAD17 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAD17 antibodies...
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RAD17 Infographic by Boster Bio
All RAD17 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, WB
$360
Cat # P02159
100 µl
Cat # P02159
100 µl
Human, Mouse
ELISA
$480
Cat # EKC1492
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1492
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC1999
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1999
1 kit, containing two 96-well plates and all necessary reagents
Anti-Rad17 Antibody Picoband®
1 Citations
Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A02159-2
100 μg/vial
Cat # A02159-2
100 μg/vial
Human
IF, IHC, ICC, WB
$370
Cat # P02159-1
100 μl/vial
Cat # P02159-1
100 μl/vial
RAD17 Overview
Facts about Cell cycle checkpoint protein RAD17.
Cell cycle checkpoint protein RAD17 (RAD17)
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin.
Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
Gene Information
| Human | |
|---|---|
| Gene Name: | RAD17 |
| Uniprot: | O75943 |
| Entrez: | 5884 |
Family
| Belongs to: |
|---|
| rad17/RAD24 family |
Alternative Names
CCYC; cell cycle checkpoint protein (RAD17); cell cycle checkpoint protein RAD17; FLJ41520; HRAD17; R24L; RAD1 (S. pombe) homolog; RAD1 homolog; RAD17 homolog (S. pombe); Rad17; Rad17-like protein; RAD17SP; RAD24; RF-C activator 1 homolog; RF-C/activator 1 homolog
Molecular Weight
Mass (kDA):
77.055 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q13.2 |
| Sequence: | 5; NC_000005.10 (69369297..69414801) |
Tissue Specificity
Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors).
Subcellular Localizations
Nucleus. Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
Diseases
- Malignant Neoplasms
- Neoplasms
- Ataxia Telangiectasia
- Ataxia
- Genomic Instability
- Genotoxic Stress
- Telangiectasis
- Carcinoma
- Malignant Neoplasm Of Lung
- Malignant Tumor Of Colon
- Neoplasm Metastasis
- Non-small Cell Lung Carcinoma
- Telomere Shortening
Interacting Proteins
- FZR1
- MRE11
- NBN
- RAD50
Pathways
- Cell Cycle
- Dna Replication
- Dna Damage Checkpoint
- Dna Repair
- S Phase
- Cell Cycle Arrest
- Cell Cycle Checkpoint
- Mitosis
- Localization
- Meiosis
- Cell Division
- Translesion Synthesis
- Dna Replication Checkpoint
PTMs
- Phosphorylation
- Methylation
Research Areas
- Cancer
- Checkpoint signaling
- DNA Double Strand Break Repair
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAD17
bosterbio.com/bosterbio-gene-info-cards/RAD17
References
PMID: 9878245 by Dean F.B., et al. cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster.
PMID: 9660800 by Parker A.E., et al. Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene.
1 Publications of Boster RAD17 Antibodies & ELISA Kits
- PubMed ID: 10.3390/genes10100768, Investigation of the Possible Role of RAD9 in Post-Diapaused Embryonic Developme...
*More publications can be found for each product on its corresponding product page