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, No Gclids
RAD21 Antibodies
AND RAD21 ELISA kits, RAD21 Proteins
Many biological assays use antibodies to detect RAD21, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAD21 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAD21 antibodies...
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RAD21 Infographic by Boster Bio
All RAD21 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M01864
100 μl
Cat # M01864
100 μl
Human, Mouse, Rat
IHC, WB
$523
Cat # M01864-1
100 µl
Cat # M01864-1
100 µl
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01864-2
100 μg/vial
Cat # A01864-2
100 μg/vial
RAD21 Overview
Facts about Double-strand-break repair protein rad21 homolog.
Double-strand-break repair protein rad21 homolog (RAD21)
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication.
The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. In metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate.
Gene Information
| Human | |
|---|---|
| Gene Name: | RAD21 |
| Uniprot: | O60216 |
| Entrez: | 5885 |
Family
| Belongs to: |
|---|
| rad21 family |
Alternative Names
double-strand-break repair protein rad21 homolog; hHR21FLJ25655; HR21; KIAA0078RAD21 (S. pombe) homolog; MCD1; Nuclear matrix protein 1; NXP-1; NXP1HRAD21; protein involved in DNA double-strand break repair; RAD21 homolog (S. pombe); SCC1 homolog; SCC1FLJ40596
Molecular Weight
Mass (kDA):
71.69 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q24.11 |
| Sequence: | 8; NC_000008.11 (116845934..116874776, complement) |
Subcellular Localizations
[Double-strand-break repair protein rad21 homolog]: Nucleus. Nucleus matrix. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Associates with chromatin (PubMed:11590136, PubMed:11073952). Before prophase, scattered along chromosome arms (PubMed:11073952). During prophase and prometaphase, most cohesins dissociate from the arms of condensing chromosome, possibly through PLK1-mediated phosphorylation (PubMed:11931760). A small amount of cohesin remains in centromeric regions and is removed from chromosomes only at the onset of anaphase. At anaphase, cleavage by separase
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Cornelia De Lange Syndrome
- Mammary Neoplasms
- Aneuploidy
- Carcinoma
- Cell Invasion
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Cell Transformation, Neoplastic
- Leukemia
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- FHL3
- PDS5A
- PDS5B
- SMC1A
- SMC3
- SSU72
- STAG2
- WAPL
Pathways
- Sister Chromatid Cohesion
- Mitosis
- Anaphase
- Chromosome Segregation
- Meiosis
- Metaphase
- S Phase
- Localization
- Dna Repair
- Prophase
- Cell Cycle
- Dna Replication
- Interphase
PTMs
- Cleavage
- Phosphorylation
- Acetylation
- Methylation
Research Areas
- Apoptosis
- Cancer
- Cell Biology
- Cell Cycle and Replication
- Chromatin Research
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAD21
bosterbio.com/bosterbio-gene-info-cards/RAD21
References
PMID: 8812457 by McKay M.J., et al. Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse.
PMID: 10931856 by Losada A., et al. Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes.