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- Table of Contents
Facts about Ras-related protein Rab-3C.
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Mouse | |
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Gene Name: | Rab3c |
Uniprot: | P62823 |
Entrez: | 67295 |
Belongs to: |
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small GTPase superfamily |
RAB3C, member RAS oncogene family; ras-related protein Rab-3C
Mass (kDA):
25.872 kDA
Mouse | |
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Location: | 13|13 D2.1 |
Sequence: | 13; |
Biological Activity, Specificity and Applications: These are the three main facets of this biomarker. Read on to discover more about its benefits and limitations. Boster Bio offers a wide selection of high-affinity primary antibodies that have been extensively validated on Western Blotting, Immunohistochemistry, and ELISA. Here are some common uses:
The Biological Activity (RAB3C) gene is studied in a variety of cancer cells and other tissues. These genes encode proteins that regulate intracellular signaling and control growth factor receptor expression. These proteins are involved both in physiological and pathological processes. This gene may also have diagnostic potential. However, it is still under investigation for its role in the development of cancer.
The Rab family of small GTPases plays a broad range of functions, including the recycling and exocytosis. Rabs function as molecular switches to regulate various macromolecular complexes, including synaptic vesicles. Numerous neurological, developmental and other disorders have been associated with mutations in RABs.
The Rab3C protein is found in the nervous system and is localized on synaptic vesicles. It cycles on/off the synaptic-vesicle membrane parallel to the exocytotic production of neurotransmitters. Rab3C is crucial for exocytosis regulation. The specificity of RAB3C markers will allow for accurate diagnosis. Rab3C is found on synaptic vesicles in both brain and spinal cord, where it regulates exocytosis and the release of neurotransmitters.
Rab3B is a key component of spatial navigation within a water maze. It also contributes in fear of extinction. Hence, the RAB3B KO significantly impairs this activity. Rab3BKO results are impaired learning and memory in Rab3B inficient mice. The Rab3C marker could play other roles in the reversal of learning and memory. These questions can be addressed with additional tools. Rab3BKO is just one example.
VGLUT1 SVs exhibited the highest number of expressions, while SV2A/B & VGAT SVs exhibited the fewest. The SVs expressed Rab3a/b and c in a different way. These results demonstrate that SVs are also able to express SYT1 (Rabb3c) and SYT2 (SYT2). In double-labeling experiments, Rab3a/c were differentially expressed in glutamatergic and GABAergic terminals.
RAB3A is a different type of receptor that plays a critical role in the brain. RAB3C and RAB3C also play important roles. The former is essential for presynaptic plasticity long-term (LTP), and Rab3B to control inhibitory synapses. Both RAB3A and RAB3B are present in the CA1 region of the hippocampus. These receptors can be found in the CA1 Region, which is rich in inhibitory synapse.
These two types are largely independent. In this study Rab3A was found co-localized to SV2A, SV2B and SV2C. The RAB3C mark co-localized well with SV2A as well as SV2B. These receptors can be found in the brains of rats. Rab3C, however, is required for baseline transmission and short-term plasticity in inhibitory synapses.
The RAB3C markers targets Rab proteins. They play a crucial role in controlling the vesicular traffic within eukaryotic cellular cells. These Rab proteins have a critical role in regulating exocytosis. Rab3C shares an amino acid identity of 77-85% with its human orthologs but has distinct subcellular targets, functional roles, and amino acids. RTPCR analysis also showed that Rab3C is expressed both in the brain and placenta of humans.
The Rab protein subfamily is made up of many members. Rabs first appeared in yeast and mammalian cells. GTP-bound and GDP-bound states alternate between Rab proteins, which correspond to active or inactive states. GTP activating proteins and guanine nuclear exchange factors, or GEFs, regulate them. Rabs are critical components of many biological processes, including the transport and assembly of DNA structures and ions.
Rab3C is an important marker for RAB3C-related disorders. Huntington's syndrome is linked to rab3c's overexpression. Rab3c is also upregulated in Huntington’s patients. It is also thought to play a part in the regeneration and maintenance of synaptic cells. Rab3C can be used as a marker to detect SNAP25 and RAB3. Numerous studies have demonstrated that the RAB3C marker helps in detecting the disease.
The neuronal function of autophagy is to clear cellular components. Autophagosomes, which are generated in distal axon, are transported back into neuronal cell bodies and destroyed by fusions with lysosomes. Autophagy pathways are regulated by the Rab proteins. RAB3C and RAB26 are two of the Rab proteins that are involved in autophagy and recycle SV.
The depolarization-evoked recruitment of synaptic vesicles is associated with an increase in the number of docked vesicles in the active zone. However, docked cells were lower in terminals that are deficient in Rab3A. These vesicles can also be measured in random sections of isolated nerve terminus terminals. If these findings prove to be true, rab3A is involved in activity-dependent transport.
PMID: 12578829 by Fukuda M.; Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.
PMID: 29125462 by Steger M., et al. Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.