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- Table of Contents
Facts about Ras-related protein Rab-39B.
Small GTPases Rab involved in autophagy.
The little GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.Rabs cycle between an inactive GDP-bound form and an energetic GTP-bound form that's able to recruit to membranes distinct sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). May be involved in vesicular trafficking (PubMed:20159109).
Mouse | |
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Gene Name: | Rab39b |
Uniprot: | Q8BHC1 |
Entrez: | 67790 |
Belongs to: |
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small GTPase superfamily |
MRX72; RAB39B, member RAS oncogene family; ras-related protein Rab-39B
Mass (kDA):
24.636 kDA
Mouse | |
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Location: | X 38.26 cM|X A7.3 |
Sequence: | X; |
Specifically expressed in neuron and neuronal precursors in the brain. Expression is high in all regions of the brain with highest levels observed in the hippocampus.
PMID: 20159109 by Giannandrea M., et al. Mutations in the small GTPase gene RAB39B are responsible for X- linked mental retardation associated with autism, epilepsy, and macrocephaly.
PMID: 23624502 by Mori Y., et al. Small GTPase Rab39A interacts with UACA and regulates the retinoic acid-induced neurite morphology of Neuro2A cells.