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- Table of Contents
Facts about Pyroglutamylated RF-amide peptide receptor.
Receptor for the orexigenic neuropeptide QRFP.
The activity of this receptor is mediated by G proteins which regulate adenylate cyclase activity and intracellular calcium levels..
Human | |
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Gene Name: | QRFPR |
Uniprot: | Q96P65 |
Entrez: | 84109 |
Belongs to: |
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G-protein coupled receptor 1 family |
AQ27; G protein-coupled receptor 103; GPR103; G-protein coupled receptor 103; MGC149217; Orexigenic neuropeptide QRFP receptor; pyroglutamylated RFamide peptide receptor; QRFP receptor; QRFPR; SP9155
Mass (kDA):
49.488 kDA
Human | |
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Location: | 4q27 |
Sequence: | 4; NC_000004.12 (121328642..121381054, complement) |
Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid.
Cell membrane; Multi-pass membrane protein.
PMID: 11574155 by Lee D.K., et al. Discovery and mapping of ten novel G protein-coupled receptor genes.
PMID: 12714592 by Jiang Y., et al. Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.