Serine protease 27 Antibodies

Serine protease 27 (PRSS27)

Gene Information

Human
Gene Name:	PRSS27
Uniprot:	Q9BQR3
Entrez:	83886

Family

Belongs to:
peptidase S1 family

Alternative Names

CAP-2; CAPH2; channel-activating protease 2; EC 3.4.21; EC 3.4.21.-; EC 3.4.21.4; EC 3.4.21.43; Marapsin; MPN; MPNMarapsin; Pancreasin; protease, serine 27; PRSS27; serine protease 27

Molecular Weight

Mass (kDA):
31.94 kDA

Genomic Context

Human
Location:	16p13.3
Sequence:	16; NC_000016.10 (2712418..2720224, complement)

Tissue Specificity

Expressed predominantly in the pancreas.

Subcellular Localizations

Secreted.

Diseases

• Adenocarcinoma
• Pancreatic Ductal Adenocarcinoma
• Psoriasis
• Corneal Diseases
• Wounds, Penetrating
• Myeloproliferative Disease
• Hyperplasia

• Ductal Breast Carcinoma

Pathways

• Proteolysis
• Wound Healing
• Localization

PTMs

• Cleavage

• Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRSS27

Boster Bio - Best Uses Of The PRSS27 Marker

You have reached the right place if your goal is to find high-affinity prim antibodies for use with the PRSS27Marker. We've highlighted some of the advantages of using the PRSS27 marker and we've also given a brief biography of Steven Boster (the man who pioneered this marker). We'll be discussing Steven Boster's history and how his contributions continue to shape the world biomedical research.

Anti-PRSS27 marker

Boster Bio was established in 1993. It specializes in the production of antibodies. Originally, the company only made ELISA tests, but has now added PCR-related molecular biology products to its portfolio. The company also provides support services for researchers and offers technical resources to aid in their research. Boster Bio provides support services to scientists 24 hours a day, including technical resources and other resources.

Primary antibodies of high-affinity

The PRSS27 gene can be used to study antibody affinity maturation. By examining the structural and thermodynamic properties of antibodies, researchers can identify the characteristics of high-affinity primary antibodies. These antibodies could potentially be a source of new therapeutics. In addition to its use in cancer immunotherapy, PRSS27-derived antibodies have other potential applications. These antibodies could be useful for detection of HIV-1 and herpes Simplex viruses.

Next-generation sequencing can also be used for antibody clonal lineage reconstruction. This method can detect germ line progenitor genes that are different to true unmutated ancestors. High-affinity primary antibodies using PRSS27 marker are able to identify mutations in the VL or VH gene segments with high certainty. However, the original VLJL and VHDJH junctional sequences are not known. Affinity maturation is also known to have insertions and deletions.

Conjugating antibody fragments with toxins is another way to increase antibody affinity. Combining the toxins with the target can allow these antibodies to penetrate the cell's membrane and destroy it. For example, scFv conjugates with Pseudomonas Exotoxin A (PEA) or TRAIL, a human cytotoxic agent.

These antibodies can be used for immunohistochemical analysis. They can recognize a variety antigens on the same tissue. The PRSS27 marker is capable of simultaneous detection for up to 61 distinct antigens from the same tissue. However, high antibody affinity can make is difficult to separate the antigen and antibody. This may lead to the need for harsh elution methods or denaturing procedures.

KD values can be used to determine the rate at which an antibody is dissociated from its ligand. It is calculated from the rate at which the two antibodies react. The higher the antibody's affinity, the lower the KD value. The concentration of reactants affects the KD values. The reaction rate is proportional with the concentration. Therefore, the higher the antibody affinity.

Steven Boster's history

Steve Boster is a man whose legacy can be traced back as far as 1993, when he invented the "The Lavatory Antbody", the first product in the field immunohistochemistry. He launched a series on products in this field. Eventually, his company grew to become the largest catalog antibody company in China. PicoKine, a platform he created that allows high-sensitivity ELISA tests to be delivered, was launched in the late 90s.

After years of retail sales, Steve Boster was a Concordia Hall member and a U.S. Army veteran. His surviving relatives include his wife Nina; 2 daughters - Natosha Peck and Crystal Boster; 6 grandchildren; and four brothers: Donald Sr. Jack Boster and Sandra Blanton. There are also many nieces and nephews.