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PKN1 Antibodies
AND PKN1 ELISA kits, PKN1 Proteins
Many biological assays use antibodies to detect PKN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PKN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PKN1 antibodies...
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PKN1 Overview
Facts about Serine/threonine-protein kinase N1.
Serine/threonine-protein kinase N1 (PKN1)
PKC-related serine/threonine-protein kinase involved in various processes like regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Section of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and contributes to the activation of MAPK14.
Regulates the cytoskeletal network by phosphorylating proteins like VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates'Ser-575','Ser-637' and'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly.
Gene Information
| Human | |
|---|---|
| Gene Name: | PKN1 |
| Uniprot: | Q16512 |
| Entrez: | 5585 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
DBK; EC 2.7.11; MGC46204; PAK1; PAK1Serine-threonine protein kinase N; PKN; PKN1; PKN-ALPHA; PKNPKN-ALPHA; PRK1; PRK1PAK-1; PRKCL1; PRKCL1protein kinase C-related kinase 1; Protease-activated kinase 1; Protein kinase C-like 1EC 2.7.11.13; Protein kinase C-like PKN; protein kinase N1; Protein kinase PKN-alpha; Protein-kinase C-related kinase 1; serine/threonine protein kinase N; serine/threonine-protein kinase N1; serine-threonine kinase N
Molecular Weight
Mass (kDA):
103.932 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.12 |
| Sequence: | 19; NC_000019.10 (14433306..14471859) |
Tissue Specificity
Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells.
Subcellular Localizations
Cytoplasm. Nucleus. Endosome. Cell membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis.
Diseases
- Malignant Neoplasms
- Neoplasms
- Salmonella Infections
- Sclerosis
- Primary Lateral Sclerosis
- Amyotrophic Lateral Sclerosis
- Mammary Neoplasms
- Haploinsufficiency
- Pharyngitis
- Neoplasm Metastasis
- Brain Ischemia
Interacting Proteins
- CCDC85B
- CDR2
- GOLGA2
- HOMER3
- KRT15
- KRT31
- MAPK12
- MID1
- SSX2IP
- VIM
Pathways
- Secretion
- Sporulation
- Rna Interference
- Transport
- Cell Migration
- Germinal Center Formation
- Muscle Cell Migration
- Virulence
- Inflammatory Response
- Cytokinesis
- Histone Phosphorylation
- Cell Division
- Sensitization
PTMs
- Phosphorylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PKN1
bosterbio.com/bosterbio-gene-info-cards/PKN1
References
PMID: 8135837 by Mukai H., et al. A novel protein kinase with leucine zipper-like sequences: its catalytic domain is highly homologous to that of protein kinase C.
PMID: 7851406 by Palmer R.H., et al. Cloning and expression patterns of two members of a novel protein- kinase-C-related kinase family.