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PDX1 Antibodies
AND PDX1 ELISA kits, PDX1 Proteins
Many biological assays use antibodies to detect PDX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDX1 antibodies...
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PDX1 Overview
Facts about Pancreas/duodenum homeobox protein 1.
Pancreas/duodenum homeobox protein 1 (PDX1)
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Especially involved in glucose-dependent regulation of insulin gene transcription.
Included in a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'.
Gene Information
| Human | |
|---|---|
| Gene Name: | PDX1 |
| Uniprot: | P52945 |
| Entrez: | 3651 |
Family
| Belongs to: |
|---|
| Antp homeobox family |
Alternative Names
Glucose-sensitive factor; IDX1; IDX-1GSF; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; Insulin upstream factor 1; IPF1; IPF1pancreas/duodenum homeobox protein 1; Islet/duodenum homeobox-1; MODY4IUF1; pancreatic and duodenal homeobox 1; pancreatic-duodenal homeobox factor 1; PDX-1; PDX-1IPF-1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1IUF-1
Molecular Weight
Mass (kDA):
30.771 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q12.2 |
| Sequence: | 13; NC_000013.11 (27919982..27926313) |
Tissue Specificity
Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).
Subcellular Localizations
Nucleus. Cytoplasm, cytosol.
Diseases
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Hyperglycemia
- Diabetes Mellitus, Insulin-dependent
- Diabetes Mellitus, Experimental
- Neoplasms
- Pancreatic Neoplasm
- Insulinoma
- Impaired Glucose Tolerance
- Malignant Neoplasms
- Insulin Resistance
- Hyperplasia
- Congenital Absence
Pathways
- Secretion
- Insulin Secretion
- Pancreas Development
- Cell Differentiation
- Regeneration
- Cell Proliferation
- Glucose Homeostasis
- Transdifferentiation
- Cell Development
- Pathogenesis
- Localization
- Cell Growth
- Cell Death
PTMs
- Phosphorylation
- Acetylation
- Methylation
- Cleavage
- Oxidation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDX1
bosterbio.com/bosterbio-gene-info-cards/PDX1
References
PMID: 7590740 by Stoffel M., et al. Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1.
PMID: 8635654 by Inoue H., et al. Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene.